Modulation of Reactive Oxygen Species to Overcome 5-Fluorouracil Resistance

5-Fluorouracil (5-FU) remains to be an important chemotherapeutic drug for treating several cancers when targeted therapy is unavailable. Chemoresistance limits the clinical utility of 5-FU, and new strategies are required to overcome the resistance. Reactive oxygen species (ROS) and antioxidants ar...

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Detalles Bibliográficos
Autores principales: Chun, Kyung-Soo, Joo, Sang Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622305/
https://www.ncbi.nlm.nih.gov/pubmed/35440517
http://dx.doi.org/10.4062/biomolther.2022.017
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author Chun, Kyung-Soo
Joo, Sang Hoon
author_facet Chun, Kyung-Soo
Joo, Sang Hoon
author_sort Chun, Kyung-Soo
collection PubMed
description 5-Fluorouracil (5-FU) remains to be an important chemotherapeutic drug for treating several cancers when targeted therapy is unavailable. Chemoresistance limits the clinical utility of 5-FU, and new strategies are required to overcome the resistance. Reactive oxygen species (ROS) and antioxidants are balanced differently in both normal and cancer cells. Modulating ROS can be one method of overcoming 5-FU resistance. This review summarizes selected compounds and endogenous cellular targets modulating ROS generation to overcome 5-FU resistance.
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spelling pubmed-96223052022-11-01 Modulation of Reactive Oxygen Species to Overcome 5-Fluorouracil Resistance Chun, Kyung-Soo Joo, Sang Hoon Biomol Ther (Seoul) Review 5-Fluorouracil (5-FU) remains to be an important chemotherapeutic drug for treating several cancers when targeted therapy is unavailable. Chemoresistance limits the clinical utility of 5-FU, and new strategies are required to overcome the resistance. Reactive oxygen species (ROS) and antioxidants are balanced differently in both normal and cancer cells. Modulating ROS can be one method of overcoming 5-FU resistance. This review summarizes selected compounds and endogenous cellular targets modulating ROS generation to overcome 5-FU resistance. The Korean Society of Applied Pharmacology 2022-11-01 2022-04-20 /pmc/articles/PMC9622305/ /pubmed/35440517 http://dx.doi.org/10.4062/biomolther.2022.017 Text en Copyright © 2022, The Korean Society of Applied Pharmacology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Chun, Kyung-Soo
Joo, Sang Hoon
Modulation of Reactive Oxygen Species to Overcome 5-Fluorouracil Resistance
title Modulation of Reactive Oxygen Species to Overcome 5-Fluorouracil Resistance
title_full Modulation of Reactive Oxygen Species to Overcome 5-Fluorouracil Resistance
title_fullStr Modulation of Reactive Oxygen Species to Overcome 5-Fluorouracil Resistance
title_full_unstemmed Modulation of Reactive Oxygen Species to Overcome 5-Fluorouracil Resistance
title_short Modulation of Reactive Oxygen Species to Overcome 5-Fluorouracil Resistance
title_sort modulation of reactive oxygen species to overcome 5-fluorouracil resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622305/
https://www.ncbi.nlm.nih.gov/pubmed/35440517
http://dx.doi.org/10.4062/biomolther.2022.017
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