Hydroxyzine Induces Cell Death in Triple-Negative Breast Cancer Cells via Mitochondrial Superoxide and Modulation of Jak2/STAT3 Signaling

Treatment of triple-negative breast cancer (TNBC) has been limited due to the lack of molecular targets. In this study, we evaluated the cytotoxicity of hydroxyzine, a histamine H1 receptor antagonist in human triple-negative breast cancer BT-20 and HCC-70 cells. Hydroxyzine inhibited the growth of...

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Detalles Bibliográficos
Autores principales: Shakya, Rajina, Park, Gyu Hwan, Joo, Sang Hoon, Shim, Jung-Hyun, Choi, Joon-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622314/
https://www.ncbi.nlm.nih.gov/pubmed/36305293
http://dx.doi.org/10.4062/biomolther.2022.121

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