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Growth Inhibitory and Pro-Apoptotic Effects of Hirsuteine in Chronic Myeloid Leukemia Cells through Targeting Sphingosine Kinase 1

Chronic myeloid leukemia (CML) is a slowly progressing hematopoietic cell disorder. Sphingosine kinase 1 (SPHK1) plays established roles in tumor initiation, progression, and chemotherapy resistance in a wide range of cancers, including leukemia. However, small-molecule inhibitors targeting SPHK1 in...

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Detalles Bibliográficos
Autores principales:	Gao, Shan, Guo, Tingting, Luo, Shuyu, Zhang, Yan, Ren, Zehao, Lang, Xiaona, Hu, Gaoyong, Zuo, Duo, Jia, Wenqing, Kong, Dexin, Yu, Haiyang, Qiu, Yuling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society of Applied Pharmacology 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622316/ https://www.ncbi.nlm.nih.gov/pubmed/35702821 http://dx.doi.org/10.4062/biomolther.2022.023

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