Is intracranial volume a risk factor for IDH-mutant low-grade glioma? A case–control study

PURPOSE: Risk of cancer has been associated with body or organ size in several studies. We sought to investigate the relationship between intracranial volume (ICV) (as a proxy for lifetime maximum brain size) and risk of IDH-mutant low-grade glioma. METHODS: In a multicenter case–control study based...

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Detalles Bibliográficos
Autores principales: Sagberg, Lisa Millgård, Fyllingen, Even Hovig, Hansen, Tor Ivar, Strand, Per Sveino, Håvik, Aril Løge, Sundstrøm, Terje, Corell, Alba, Jakola, Asgeir Store, Salvesen, Øyvind, Solheim, Ole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622551/
https://www.ncbi.nlm.nih.gov/pubmed/36029398
http://dx.doi.org/10.1007/s11060-022-04120-6
Descripción
Sumario:PURPOSE: Risk of cancer has been associated with body or organ size in several studies. We sought to investigate the relationship between intracranial volume (ICV) (as a proxy for lifetime maximum brain size) and risk of IDH-mutant low-grade glioma. METHODS: In a multicenter case–control study based on population-based data, we included 154 patients with IDH-mutant WHO grade 2 glioma and 995 healthy controls. ICV in both groups was calculated from 3D MRI brain scans using an automated reverse brain mask method, and then compared using a binomial logistic regression model. RESULTS: We found a non-linear association between ICV and risk of glioma with increasing risk above and below a threshold of 1394 ml (p < 0.001). After adjusting for ICV, sex was not a risk factor for glioma. CONCLUSION: Intracranial volume may be a risk factor for IDH-mutant low-grade glioma, but the relationship seems to be non-linear with increased risk both above and below a threshold in intracranial volume.

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