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Efficacy and Dosage Pattern of Sacubitril/Valsartan in Chinese Heart Failure with Reduced Ejection Fraction Patients
This study aims to investigate the dosage pattern, efficacy, and safety of sacubitril/valsartan (Sac/Val) in Chinese heart failure with reduced ejection fraction (HFrEF) patients regarding real-world settings. Patients from 27 centers with a confirmed diagnosis of HFrEF and initiated Sac/Val treatme...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622556/ https://www.ncbi.nlm.nih.gov/pubmed/35505156 http://dx.doi.org/10.1007/s12265-022-10236-x |
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author | Cheang, Iokfai Shi, Shi Lu, Xinyi Liao, Shengen Zhu, Xu Su, Xi Lu, Qi Yuan, Jing Xu, Dachun Zhang, Min Dai, Cuilian Wang, Jingfeng Yuan, Fang Zhao, Yan Zhou, Jingmin Li, Xinli |
author_facet | Cheang, Iokfai Shi, Shi Lu, Xinyi Liao, Shengen Zhu, Xu Su, Xi Lu, Qi Yuan, Jing Xu, Dachun Zhang, Min Dai, Cuilian Wang, Jingfeng Yuan, Fang Zhao, Yan Zhou, Jingmin Li, Xinli |
author_sort | Cheang, Iokfai |
collection | PubMed |
description | This study aims to investigate the dosage pattern, efficacy, and safety of sacubitril/valsartan (Sac/Val) in Chinese heart failure with reduced ejection fraction (HFrEF) patients regarding real-world settings. Patients from 27 centers with a confirmed diagnosis of HFrEF and initiated Sac/Val treatment were enrolled. The primary objective was to evaluate the dosage pattern and change of heart failure status. In a final cohort of 983 patients, outpatient Sac/Val treatment demonstrated a similar beneficial effect in NT-proBNP and cardiac function. After initiating the treatment, overall and sub-population showed similar safety and efficacy. Patients who received a higher dose of Sac/Val (> 200 mg/d) demonstrated better improvement in LV function and reduction of NT-proBNP regardless of adjustment. Among Chinese HFrEF patients, Sac/Val showed a comparable reduction in NT-proBNP and improvement in cardiac function. Data further support guideline recommendations of Sac/Val in Chinese population. Optimal up-titration might provide further benefits. Further long-term and prognostic studies are needed. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-9622556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-96225562022-11-02 Efficacy and Dosage Pattern of Sacubitril/Valsartan in Chinese Heart Failure with Reduced Ejection Fraction Patients Cheang, Iokfai Shi, Shi Lu, Xinyi Liao, Shengen Zhu, Xu Su, Xi Lu, Qi Yuan, Jing Xu, Dachun Zhang, Min Dai, Cuilian Wang, Jingfeng Yuan, Fang Zhao, Yan Zhou, Jingmin Li, Xinli J Cardiovasc Transl Res Original Article This study aims to investigate the dosage pattern, efficacy, and safety of sacubitril/valsartan (Sac/Val) in Chinese heart failure with reduced ejection fraction (HFrEF) patients regarding real-world settings. Patients from 27 centers with a confirmed diagnosis of HFrEF and initiated Sac/Val treatment were enrolled. The primary objective was to evaluate the dosage pattern and change of heart failure status. In a final cohort of 983 patients, outpatient Sac/Val treatment demonstrated a similar beneficial effect in NT-proBNP and cardiac function. After initiating the treatment, overall and sub-population showed similar safety and efficacy. Patients who received a higher dose of Sac/Val (> 200 mg/d) demonstrated better improvement in LV function and reduction of NT-proBNP regardless of adjustment. Among Chinese HFrEF patients, Sac/Val showed a comparable reduction in NT-proBNP and improvement in cardiac function. Data further support guideline recommendations of Sac/Val in Chinese population. Optimal up-titration might provide further benefits. Further long-term and prognostic studies are needed. GRAPHICAL ABSTRACT: [Image: see text] Springer US 2022-05-03 2022 /pmc/articles/PMC9622556/ /pubmed/35505156 http://dx.doi.org/10.1007/s12265-022-10236-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Cheang, Iokfai Shi, Shi Lu, Xinyi Liao, Shengen Zhu, Xu Su, Xi Lu, Qi Yuan, Jing Xu, Dachun Zhang, Min Dai, Cuilian Wang, Jingfeng Yuan, Fang Zhao, Yan Zhou, Jingmin Li, Xinli Efficacy and Dosage Pattern of Sacubitril/Valsartan in Chinese Heart Failure with Reduced Ejection Fraction Patients |
title | Efficacy and Dosage Pattern of Sacubitril/Valsartan in Chinese Heart Failure with Reduced Ejection Fraction Patients |
title_full | Efficacy and Dosage Pattern of Sacubitril/Valsartan in Chinese Heart Failure with Reduced Ejection Fraction Patients |
title_fullStr | Efficacy and Dosage Pattern of Sacubitril/Valsartan in Chinese Heart Failure with Reduced Ejection Fraction Patients |
title_full_unstemmed | Efficacy and Dosage Pattern of Sacubitril/Valsartan in Chinese Heart Failure with Reduced Ejection Fraction Patients |
title_short | Efficacy and Dosage Pattern of Sacubitril/Valsartan in Chinese Heart Failure with Reduced Ejection Fraction Patients |
title_sort | efficacy and dosage pattern of sacubitril/valsartan in chinese heart failure with reduced ejection fraction patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622556/ https://www.ncbi.nlm.nih.gov/pubmed/35505156 http://dx.doi.org/10.1007/s12265-022-10236-x |
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