Ferulic Acid Alleviates Atherosclerotic Plaques by Inhibiting VSMC Proliferation Through the NO/p21 Signaling pathway

The benefits and risks of inhibiting the proliferation and migration of vascular smooth muscle cells (VSMCs) in atherosclerosis (AS) remain a subject of debate. In this study, we investigated the effect of ferulic acid (FA) on the proliferation and migration of VSMCs induced by platelet-derived grow...

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Autores principales: Wu, Xiaoyun, Hu, Ziwei, Zhou, Junjie, Liu, Jin, Ren, Ping, Huang, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622559/
https://www.ncbi.nlm.nih.gov/pubmed/34993756
http://dx.doi.org/10.1007/s12265-021-10196-8
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author Wu, Xiaoyun
Hu, Ziwei
Zhou, Junjie
Liu, Jin
Ren, Ping
Huang, Xi
author_facet Wu, Xiaoyun
Hu, Ziwei
Zhou, Junjie
Liu, Jin
Ren, Ping
Huang, Xi
author_sort Wu, Xiaoyun
collection PubMed
description The benefits and risks of inhibiting the proliferation and migration of vascular smooth muscle cells (VSMCs) in atherosclerosis (AS) remain a subject of debate. In this study, we investigated the effect of ferulic acid (FA) on the proliferation and migration of VSMCs induced by platelet-derived growth factor (PDGF) and the associated mechanism and used ApoE(-/-) mice to study whether the effect of FA on VSMC proliferation and migration is beneficial in alleviating AS plaques. It was found that FA not only reduced blood lipid levels but also promoted the production of nitric oxide (NO) by MOVAS cells through the endothelial nitric oxide synthase (eNOS) pathway, inhibited the migration and proliferation of VSMCs induced by PDGF, promoted the expression of p21 in VSMCs, and exerted a therapeutic effect against AS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12265-021-10196-8.
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spelling pubmed-96225592022-11-02 Ferulic Acid Alleviates Atherosclerotic Plaques by Inhibiting VSMC Proliferation Through the NO/p21 Signaling pathway Wu, Xiaoyun Hu, Ziwei Zhou, Junjie Liu, Jin Ren, Ping Huang, Xi J Cardiovasc Transl Res Original Article The benefits and risks of inhibiting the proliferation and migration of vascular smooth muscle cells (VSMCs) in atherosclerosis (AS) remain a subject of debate. In this study, we investigated the effect of ferulic acid (FA) on the proliferation and migration of VSMCs induced by platelet-derived growth factor (PDGF) and the associated mechanism and used ApoE(-/-) mice to study whether the effect of FA on VSMC proliferation and migration is beneficial in alleviating AS plaques. It was found that FA not only reduced blood lipid levels but also promoted the production of nitric oxide (NO) by MOVAS cells through the endothelial nitric oxide synthase (eNOS) pathway, inhibited the migration and proliferation of VSMCs induced by PDGF, promoted the expression of p21 in VSMCs, and exerted a therapeutic effect against AS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12265-021-10196-8. Springer US 2022-01-06 2022 /pmc/articles/PMC9622559/ /pubmed/34993756 http://dx.doi.org/10.1007/s12265-021-10196-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Wu, Xiaoyun
Hu, Ziwei
Zhou, Junjie
Liu, Jin
Ren, Ping
Huang, Xi
Ferulic Acid Alleviates Atherosclerotic Plaques by Inhibiting VSMC Proliferation Through the NO/p21 Signaling pathway
title Ferulic Acid Alleviates Atherosclerotic Plaques by Inhibiting VSMC Proliferation Through the NO/p21 Signaling pathway
title_full Ferulic Acid Alleviates Atherosclerotic Plaques by Inhibiting VSMC Proliferation Through the NO/p21 Signaling pathway
title_fullStr Ferulic Acid Alleviates Atherosclerotic Plaques by Inhibiting VSMC Proliferation Through the NO/p21 Signaling pathway
title_full_unstemmed Ferulic Acid Alleviates Atherosclerotic Plaques by Inhibiting VSMC Proliferation Through the NO/p21 Signaling pathway
title_short Ferulic Acid Alleviates Atherosclerotic Plaques by Inhibiting VSMC Proliferation Through the NO/p21 Signaling pathway
title_sort ferulic acid alleviates atherosclerotic plaques by inhibiting vsmc proliferation through the no/p21 signaling pathway
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622559/
https://www.ncbi.nlm.nih.gov/pubmed/34993756
http://dx.doi.org/10.1007/s12265-021-10196-8
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