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Association between mean platelet volume and obstructive sleep apnea-hypopnea syndrome in children
To evaluate the correlation between mean platelet volume (MPV) and obstructive sleep apnea-hypopnea syndrome (OSAHS) in children, and to explore the diagnostic value of MPV for OSAHS. Children with OSAHS diagnosed by polysomnography (PSG) at Fuyong People’s Hospital of Bao’an District/Shenzhen Child...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622644/ https://www.ncbi.nlm.nih.gov/pubmed/36316893 http://dx.doi.org/10.1097/MD.0000000000031505 |
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author | Zeng, Guo-hui Xu, Guo Liu, Hong-yu Gao, Zhong |
author_facet | Zeng, Guo-hui Xu, Guo Liu, Hong-yu Gao, Zhong |
author_sort | Zeng, Guo-hui |
collection | PubMed |
description | To evaluate the correlation between mean platelet volume (MPV) and obstructive sleep apnea-hypopnea syndrome (OSAHS) in children, and to explore the diagnostic value of MPV for OSAHS. Children with OSAHS diagnosed by polysomnography (PSG) at Fuyong People’s Hospital of Bao’an District/Shenzhen Children’s Hospital from January 2020 to January 2021 were enrolled in this study. MPV in peripheral venous blood of the enrolled children was detected. Based on the PSG results (apnea-hypopnea index [AHI] and lowest oxygen saturation [LSaO(2)]), illness severity was classified, and correlations between the 2 parameters were statistically analyzed. A total of 190 children (males = 135, females = 55) with OSAHS were enrolled in the study. There were no significant correlations between AHI, LSaO(2), white blood cell count, red blood cell count, blood platelets, hemoglobin, and packed cell volume (P > .05), but there was a significant positive correlation between AHI and MPV (R > 0, P < .05). There was a significant negative correlation between the LSaO(2) index and MPV (R > 0, P < .05). In addition, the receiver operating characteristic (ROC) curve indicated that the best cutoff value for MPV to diagnose mild and moderate-to-severe disease conditions was 9.35 fl, and the coincidence rates for these 2 disease conditions were 93% and 80%, respectively. The ROC curve was also optimal for the diagnosis of mild and moderate-to-severe hypoxia. The critical value was 8.85 fl, and the coincidence rates for these 2 conditions were 96.4% and 76.3%, respectively. In children with OSAHS, MPV is positively correlated with AHI and negatively correlated with the LSaO(2) index of PSG. Based on the results of ROC curve analysis, MPV can be used as an auxiliary diagnostic index to judge the severity of OSAHS and the degree of hypoxia in children. |
format | Online Article Text |
id | pubmed-9622644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-96226442022-11-03 Association between mean platelet volume and obstructive sleep apnea-hypopnea syndrome in children Zeng, Guo-hui Xu, Guo Liu, Hong-yu Gao, Zhong Medicine (Baltimore) 6200 To evaluate the correlation between mean platelet volume (MPV) and obstructive sleep apnea-hypopnea syndrome (OSAHS) in children, and to explore the diagnostic value of MPV for OSAHS. Children with OSAHS diagnosed by polysomnography (PSG) at Fuyong People’s Hospital of Bao’an District/Shenzhen Children’s Hospital from January 2020 to January 2021 were enrolled in this study. MPV in peripheral venous blood of the enrolled children was detected. Based on the PSG results (apnea-hypopnea index [AHI] and lowest oxygen saturation [LSaO(2)]), illness severity was classified, and correlations between the 2 parameters were statistically analyzed. A total of 190 children (males = 135, females = 55) with OSAHS were enrolled in the study. There were no significant correlations between AHI, LSaO(2), white blood cell count, red blood cell count, blood platelets, hemoglobin, and packed cell volume (P > .05), but there was a significant positive correlation between AHI and MPV (R > 0, P < .05). There was a significant negative correlation between the LSaO(2) index and MPV (R > 0, P < .05). In addition, the receiver operating characteristic (ROC) curve indicated that the best cutoff value for MPV to diagnose mild and moderate-to-severe disease conditions was 9.35 fl, and the coincidence rates for these 2 disease conditions were 93% and 80%, respectively. The ROC curve was also optimal for the diagnosis of mild and moderate-to-severe hypoxia. The critical value was 8.85 fl, and the coincidence rates for these 2 conditions were 96.4% and 76.3%, respectively. In children with OSAHS, MPV is positively correlated with AHI and negatively correlated with the LSaO(2) index of PSG. Based on the results of ROC curve analysis, MPV can be used as an auxiliary diagnostic index to judge the severity of OSAHS and the degree of hypoxia in children. Lippincott Williams & Wilkins 2022-10-28 /pmc/articles/PMC9622644/ /pubmed/36316893 http://dx.doi.org/10.1097/MD.0000000000031505 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | 6200 Zeng, Guo-hui Xu, Guo Liu, Hong-yu Gao, Zhong Association between mean platelet volume and obstructive sleep apnea-hypopnea syndrome in children |
title | Association between mean platelet volume and obstructive sleep apnea-hypopnea syndrome in children |
title_full | Association between mean platelet volume and obstructive sleep apnea-hypopnea syndrome in children |
title_fullStr | Association between mean platelet volume and obstructive sleep apnea-hypopnea syndrome in children |
title_full_unstemmed | Association between mean platelet volume and obstructive sleep apnea-hypopnea syndrome in children |
title_short | Association between mean platelet volume and obstructive sleep apnea-hypopnea syndrome in children |
title_sort | association between mean platelet volume and obstructive sleep apnea-hypopnea syndrome in children |
topic | 6200 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622644/ https://www.ncbi.nlm.nih.gov/pubmed/36316893 http://dx.doi.org/10.1097/MD.0000000000031505 |
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