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Hereditary spastic paraplegia SPG13 mutation increases structural stability and ATPase activity of human mitochondrial chaperonin

Human mitochondrial chaperonin mHsp60 is broadly associated with various human health conditions and the V72I mutation in mHsp60 causes a form of hereditary spastic paraplegia, a neurodegenerative disease. The main function of mHsp60 is to assist folding of mitochondrial proteins in an ATP-dependent...

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Detalles Bibliográficos
Autores principales:	Chen, Lingling, Syed, Aiza, Balaji, Adhitya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622745/ https://www.ncbi.nlm.nih.gov/pubmed/36316435 http://dx.doi.org/10.1038/s41598-022-21993-9

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