Tumor extracellular vesicles mediate anti-PD-L1 therapy resistance by decoying anti-PD-L1

PD-L1(+) tumor-derived extracellular vesicles (TEVs) cause systemic immunosuppression and possibly resistance to anti-PD-L1 antibody (αPD-L1) blockade. However, whether and how PD-L1(+) TEVs mediate αPD-L1 therapy resistance is unknown. Here, we show that PD-L1(+) TEVs substantially decoy αPD-L1 and...

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Detalles Bibliográficos
Autores principales: Chen, Jiming, Yang, Jie, Wang, Wenhui, Guo, Danfeng, Zhang, Chengyan, Wang, Shibo, Lu, Xinliang, Huang, Xiaofang, Wang, Pingli, Zhang, Gensheng, Zhang, Jing, Wang, Jianli, Cai, Zhijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622748/
https://www.ncbi.nlm.nih.gov/pubmed/36220994
http://dx.doi.org/10.1038/s41423-022-00926-6

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