Mechanism of N-0385 blocking SARS-CoV-2 to treat COVID-19 based on molecular docking and molecular dynamics

PURPOSE: 2019 Coronavirus disease (COVID-19) has caused millions of confirmed cases and deaths worldwide. TMPRSS2-mediated hydrolysis and maturation of spike protein is essential for SARS-CoV-2 infection in vivo. The latest research found that a TMPRSS2 inhibitor called N-0385 could effectively prev...

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Detalles Bibliográficos
Autores principales: Cao, Jun-Feng, Yang, Xingyu, Xiong, Li, Wu, Mei, Chen, Shengyan, Xiong, Chenyang, He, Peiyong, Zong, Yonghua, Zhang, Lixin, Fu, Hongjiao, Qi, Yue, Ying, Xiran, Liu, Dengxin, Hu, Xiaosong, Zhang, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622768/
https://www.ncbi.nlm.nih.gov/pubmed/36329841
http://dx.doi.org/10.3389/fmicb.2022.1013911

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