Nrf2 regulates the arginase 1(+) microglia phenotype through the initiation of TREM2 transcription, ameliorating depression-like behavior in mice

The expression of the triggering receptor on myeloid cell-2 (TREM2) knockdown in microglia from the lateral habenula (LHb) reportedly induces depression-like behaviors in mice. However, the key molecular mechanism that mediates major depressive disorder (MDD) pathogenesis remains elusive. We herein...

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Detalles Bibliográficos
Autores principales: He, Lujuan, Zheng, Yi, Huang, Lixuan, Ye, Jingyi, Ye, Yinyi, Luo, Hanyue, Chen, Xi, Yao, Wei, Chen, Jiaxu, Zhang, Ji-chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622811/
https://www.ncbi.nlm.nih.gov/pubmed/36316319
http://dx.doi.org/10.1038/s41398-022-02227-y

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