Network analysis reveals that the tumor suppressor lncRNA GAS5 acts as a double-edged sword in response to DNA damage in gastric cancer

The lncRNA GAS5 acts as a tumor suppressor and is downregulated in gastric cancer (GC). In contrast, E2F1, an important transcription factor and tumor promoter, directly inhibits miR-34c expression in GC cell lines. Furthermore, in the corresponding GC cell lines, lncRNA GAS5 directly targets E2F1....

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Detalles Bibliográficos
Autores principales: Gupta, Shantanu, Panda, Pritam Kumar, Luo, Wei, Hashimoto, Ronaldo F., Ahuja, Rajeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622883/
https://www.ncbi.nlm.nih.gov/pubmed/36316351
http://dx.doi.org/10.1038/s41598-022-21492-x

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