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Plasma membrane flipping of Syntaxin-2 regulates its inhibitory action on insulin granule exocytosis

Enhancing pancreatic β-cell secretion is a primary therapeutic target for type-2 diabetes (T2D). Syntaxin-2 (Stx2) has just been identified to be an inhibitory SNARE for insulin granule exocytosis, holding potential as a treatment for T2D, yet its molecular underpinnings remain unclear. We show that...

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Detalles Bibliográficos
Autores principales:	Kang, Fei, Xie, Li, Qin, Tairan, Miao, Yifan, Kang, Youhou, Takahashi, Toshimasa, Liang, Tao, Xie, Huanli, Gaisano, Herbert Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622911/ https://www.ncbi.nlm.nih.gov/pubmed/36316316 http://dx.doi.org/10.1038/s41467-022-33986-3

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