Evolving understanding of antibody-dependent enhancement (ADE) of SARS-CoV-2

Since immune system and internal environment in vivo are large and complex, the interpretation of the observed immune effect from the perspective of a single immune cell or antibody seems a little feeble. Many studies have shown that specific antibodies against “ former” viruses have a reduced abili...

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Detalles Bibliográficos
Autores principales: Yang, Yalong, Xu, Fenghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622928/
https://www.ncbi.nlm.nih.gov/pubmed/36330519
http://dx.doi.org/10.3389/fimmu.2022.1008285
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author Yang, Yalong
Xu, Fenghua
author_facet Yang, Yalong
Xu, Fenghua
author_sort Yang, Yalong
collection PubMed
description Since immune system and internal environment in vivo are large and complex, the interpretation of the observed immune effect from the perspective of a single immune cell or antibody seems a little feeble. Many studies have shown that specific antibodies against “ former” viruses have a reduced ability to neutralize “new” mutant strains. However, there is no comprehensive and clear view of whether there will be Antibody-dependent enhancement (ADE). We review the latest relevant studies, hoping to explain the ADE of SARS-CoV-2 infection sometimes observed in some patients.
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spelling pubmed-96229282022-11-02 Evolving understanding of antibody-dependent enhancement (ADE) of SARS-CoV-2 Yang, Yalong Xu, Fenghua Front Immunol Immunology Since immune system and internal environment in vivo are large and complex, the interpretation of the observed immune effect from the perspective of a single immune cell or antibody seems a little feeble. Many studies have shown that specific antibodies against “ former” viruses have a reduced ability to neutralize “new” mutant strains. However, there is no comprehensive and clear view of whether there will be Antibody-dependent enhancement (ADE). We review the latest relevant studies, hoping to explain the ADE of SARS-CoV-2 infection sometimes observed in some patients. Frontiers Media S.A. 2022-10-18 /pmc/articles/PMC9622928/ /pubmed/36330519 http://dx.doi.org/10.3389/fimmu.2022.1008285 Text en Copyright © 2022 Yang and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Yang, Yalong
Xu, Fenghua
Evolving understanding of antibody-dependent enhancement (ADE) of SARS-CoV-2
title Evolving understanding of antibody-dependent enhancement (ADE) of SARS-CoV-2
title_full Evolving understanding of antibody-dependent enhancement (ADE) of SARS-CoV-2
title_fullStr Evolving understanding of antibody-dependent enhancement (ADE) of SARS-CoV-2
title_full_unstemmed Evolving understanding of antibody-dependent enhancement (ADE) of SARS-CoV-2
title_short Evolving understanding of antibody-dependent enhancement (ADE) of SARS-CoV-2
title_sort evolving understanding of antibody-dependent enhancement (ade) of sars-cov-2
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622928/
https://www.ncbi.nlm.nih.gov/pubmed/36330519
http://dx.doi.org/10.3389/fimmu.2022.1008285
work_keys_str_mv AT yangyalong evolvingunderstandingofantibodydependentenhancementadeofsarscov2
AT xufenghua evolvingunderstandingofantibodydependentenhancementadeofsarscov2

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