Soluble mediators in the function of the epidermal-immune-neuro unit in the skin

Skin is the largest, environmentally exposed (barrier) organ, capable of integrating various signals into effective defensive responses. The functional significance of interactions among the epidermis and the immune and nervous systems in regulating and maintaining skin barrier function is only now...

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Autores principales: Oleszycka, Ewa, Kwiecien, Kamila, Kwiecinska, Patrycja, Morytko, Agnieszka, Pocalun, Natalia, Camacho, Michelle, Brzoza, Piotr, Zabel, Brian A., Cichy, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623011/
https://www.ncbi.nlm.nih.gov/pubmed/36330530
http://dx.doi.org/10.3389/fimmu.2022.1003970
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author Oleszycka, Ewa
Kwiecien, Kamila
Kwiecinska, Patrycja
Morytko, Agnieszka
Pocalun, Natalia
Camacho, Michelle
Brzoza, Piotr
Zabel, Brian A.
Cichy, Joanna
author_facet Oleszycka, Ewa
Kwiecien, Kamila
Kwiecinska, Patrycja
Morytko, Agnieszka
Pocalun, Natalia
Camacho, Michelle
Brzoza, Piotr
Zabel, Brian A.
Cichy, Joanna
author_sort Oleszycka, Ewa
collection PubMed
description Skin is the largest, environmentally exposed (barrier) organ, capable of integrating various signals into effective defensive responses. The functional significance of interactions among the epidermis and the immune and nervous systems in regulating and maintaining skin barrier function is only now becoming recognized in relation to skin pathophysiology. This review focuses on newly described pathways that involve soluble mediator-mediated crosstalk between these compartments. Dysregulation of these connections can lead to chronic inflammatory diseases and/or pathologic conditions associated with chronic pain or itch.
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spelling pubmed-96230112022-11-02 Soluble mediators in the function of the epidermal-immune-neuro unit in the skin Oleszycka, Ewa Kwiecien, Kamila Kwiecinska, Patrycja Morytko, Agnieszka Pocalun, Natalia Camacho, Michelle Brzoza, Piotr Zabel, Brian A. Cichy, Joanna Front Immunol Immunology Skin is the largest, environmentally exposed (barrier) organ, capable of integrating various signals into effective defensive responses. The functional significance of interactions among the epidermis and the immune and nervous systems in regulating and maintaining skin barrier function is only now becoming recognized in relation to skin pathophysiology. This review focuses on newly described pathways that involve soluble mediator-mediated crosstalk between these compartments. Dysregulation of these connections can lead to chronic inflammatory diseases and/or pathologic conditions associated with chronic pain or itch. Frontiers Media S.A. 2022-10-18 /pmc/articles/PMC9623011/ /pubmed/36330530 http://dx.doi.org/10.3389/fimmu.2022.1003970 Text en Copyright © 2022 Oleszycka, Kwiecien, Kwiecinska, Morytko, Pocalun, Camacho, Brzoza, Zabel and Cichy https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Oleszycka, Ewa
Kwiecien, Kamila
Kwiecinska, Patrycja
Morytko, Agnieszka
Pocalun, Natalia
Camacho, Michelle
Brzoza, Piotr
Zabel, Brian A.
Cichy, Joanna
Soluble mediators in the function of the epidermal-immune-neuro unit in the skin
title Soluble mediators in the function of the epidermal-immune-neuro unit in the skin
title_full Soluble mediators in the function of the epidermal-immune-neuro unit in the skin
title_fullStr Soluble mediators in the function of the epidermal-immune-neuro unit in the skin
title_full_unstemmed Soluble mediators in the function of the epidermal-immune-neuro unit in the skin
title_short Soluble mediators in the function of the epidermal-immune-neuro unit in the skin
title_sort soluble mediators in the function of the epidermal-immune-neuro unit in the skin
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623011/
https://www.ncbi.nlm.nih.gov/pubmed/36330530
http://dx.doi.org/10.3389/fimmu.2022.1003970
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