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Sex-based considerations for implementation of ventricular assist device therapy

Women with advanced heart failure receive advanced surgical therapies such as durable left ventricular assist device (LVAD) implantation or heart transplantation at a rate much lower compared to males. Reasons for this discrepancy remain largely unknown. Much of what is understood reflects outcomes...

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Detalles Bibliográficos
Autores principales: Jones-Ungerleider, K. Candis, Rose, Angela, Knott, Kevin, Comstock, Sarah, Haft, Jonathan W., Pagani, Francis D., Tang, Paul C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623015/
https://www.ncbi.nlm.nih.gov/pubmed/36330008
http://dx.doi.org/10.3389/fcvm.2022.1011192
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author Jones-Ungerleider, K. Candis
Rose, Angela
Knott, Kevin
Comstock, Sarah
Haft, Jonathan W.
Pagani, Francis D.
Tang, Paul C.
author_facet Jones-Ungerleider, K. Candis
Rose, Angela
Knott, Kevin
Comstock, Sarah
Haft, Jonathan W.
Pagani, Francis D.
Tang, Paul C.
author_sort Jones-Ungerleider, K. Candis
collection PubMed
description Women with advanced heart failure receive advanced surgical therapies such as durable left ventricular assist device (LVAD) implantation or heart transplantation at a rate much lower compared to males. Reasons for this discrepancy remain largely unknown. Much of what is understood reflects outcomes of those patients who ultimately receive device implant or heart transplantation. Females have been shown to have a higher mortality following LVAD implantation and experience higher rates of bleeding and clotting phenomena and right ventricular failure. Beyond outcomes, the literature is limited in the identification of pre-operative factors that drive lower than expected LVAD implant rates in this population. More focused research is needed to define the disparities in advance heart failure therapy delivery in women and other underserved populations.
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spelling pubmed-96230152022-11-02 Sex-based considerations for implementation of ventricular assist device therapy Jones-Ungerleider, K. Candis Rose, Angela Knott, Kevin Comstock, Sarah Haft, Jonathan W. Pagani, Francis D. Tang, Paul C. Front Cardiovasc Med Cardiovascular Medicine Women with advanced heart failure receive advanced surgical therapies such as durable left ventricular assist device (LVAD) implantation or heart transplantation at a rate much lower compared to males. Reasons for this discrepancy remain largely unknown. Much of what is understood reflects outcomes of those patients who ultimately receive device implant or heart transplantation. Females have been shown to have a higher mortality following LVAD implantation and experience higher rates of bleeding and clotting phenomena and right ventricular failure. Beyond outcomes, the literature is limited in the identification of pre-operative factors that drive lower than expected LVAD implant rates in this population. More focused research is needed to define the disparities in advance heart failure therapy delivery in women and other underserved populations. Frontiers Media S.A. 2022-10-18 /pmc/articles/PMC9623015/ /pubmed/36330008 http://dx.doi.org/10.3389/fcvm.2022.1011192 Text en Copyright © 2022 Jones-Ungerleider, Rose, Knott, Comstock, Haft, Pagani and Tang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Jones-Ungerleider, K. Candis
Rose, Angela
Knott, Kevin
Comstock, Sarah
Haft, Jonathan W.
Pagani, Francis D.
Tang, Paul C.
Sex-based considerations for implementation of ventricular assist device therapy
title Sex-based considerations for implementation of ventricular assist device therapy
title_full Sex-based considerations for implementation of ventricular assist device therapy
title_fullStr Sex-based considerations for implementation of ventricular assist device therapy
title_full_unstemmed Sex-based considerations for implementation of ventricular assist device therapy
title_short Sex-based considerations for implementation of ventricular assist device therapy
title_sort sex-based considerations for implementation of ventricular assist device therapy
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623015/
https://www.ncbi.nlm.nih.gov/pubmed/36330008
http://dx.doi.org/10.3389/fcvm.2022.1011192
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