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First clinical applications for the NIR-II imaging with ICG in microsurgery
In microsurgery, it is always difficult to accurately identify the blood supply with ease, such as vascular anastomosis, digit replantation, skin avulsion reconstruction and flap transplantation. Near-infrared window I (NIR-I, 700—900 nm) imaging has many clinical applications, whereas near-infrared...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623121/ https://www.ncbi.nlm.nih.gov/pubmed/36329697 http://dx.doi.org/10.3389/fbioe.2022.1042546 |
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author | Wu, Yifan Suo, Yongkuan Wang, Zheng Yu, Yifeng Duan, Shuang Liu, Hongguang Qi, Baiwen Jian, Chao Hu, Xiang Zhang, Dong Yu, Aixi Cheng, Zhen |
author_facet | Wu, Yifan Suo, Yongkuan Wang, Zheng Yu, Yifeng Duan, Shuang Liu, Hongguang Qi, Baiwen Jian, Chao Hu, Xiang Zhang, Dong Yu, Aixi Cheng, Zhen |
author_sort | Wu, Yifan |
collection | PubMed |
description | In microsurgery, it is always difficult to accurately identify the blood supply with ease, such as vascular anastomosis, digit replantation, skin avulsion reconstruction and flap transplantation. Near-infrared window I (NIR-I, 700—900 nm) imaging has many clinical applications, whereas near-infrared window II (NIR-II, 1,000–1700 nm) imaging has emerged as a highly promising novel optical imaging modality and used in a few clinical fields recently, especially its penetration distance and noninvasive characteristics coincide with the needs of microsurgery. Therefore, a portable NIR-II imaging instrument and the Food and Drug Administration (FDA) approved indocyanine green (ICG) were used to improve the operation efficiency in microsurgery of 39 patients in this study. The anastomotic vessels and the salvaged distal limbs were clearly visualized after intravenous injection of ICG. The technique enabled identification of perforator vessels and estimation of perforator areas prior to the flap obtention and made it easier to monitor the prognosis. Overall, this study highlights the use of the portable NIR- II imaging with ICG as an operative evaluation tool can enhance the safety and accuracy of microsurgery. |
format | Online Article Text |
id | pubmed-9623121 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96231212022-11-02 First clinical applications for the NIR-II imaging with ICG in microsurgery Wu, Yifan Suo, Yongkuan Wang, Zheng Yu, Yifeng Duan, Shuang Liu, Hongguang Qi, Baiwen Jian, Chao Hu, Xiang Zhang, Dong Yu, Aixi Cheng, Zhen Front Bioeng Biotechnol Bioengineering and Biotechnology In microsurgery, it is always difficult to accurately identify the blood supply with ease, such as vascular anastomosis, digit replantation, skin avulsion reconstruction and flap transplantation. Near-infrared window I (NIR-I, 700—900 nm) imaging has many clinical applications, whereas near-infrared window II (NIR-II, 1,000–1700 nm) imaging has emerged as a highly promising novel optical imaging modality and used in a few clinical fields recently, especially its penetration distance and noninvasive characteristics coincide with the needs of microsurgery. Therefore, a portable NIR-II imaging instrument and the Food and Drug Administration (FDA) approved indocyanine green (ICG) were used to improve the operation efficiency in microsurgery of 39 patients in this study. The anastomotic vessels and the salvaged distal limbs were clearly visualized after intravenous injection of ICG. The technique enabled identification of perforator vessels and estimation of perforator areas prior to the flap obtention and made it easier to monitor the prognosis. Overall, this study highlights the use of the portable NIR- II imaging with ICG as an operative evaluation tool can enhance the safety and accuracy of microsurgery. Frontiers Media S.A. 2022-10-18 /pmc/articles/PMC9623121/ /pubmed/36329697 http://dx.doi.org/10.3389/fbioe.2022.1042546 Text en Copyright © 2022 Wu, Suo, Wang, Yu, Duan, Liu, Qi, Jian, Hu, Zhang, Yu and Cheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Wu, Yifan Suo, Yongkuan Wang, Zheng Yu, Yifeng Duan, Shuang Liu, Hongguang Qi, Baiwen Jian, Chao Hu, Xiang Zhang, Dong Yu, Aixi Cheng, Zhen First clinical applications for the NIR-II imaging with ICG in microsurgery |
title | First clinical applications for the NIR-II imaging with ICG in microsurgery |
title_full | First clinical applications for the NIR-II imaging with ICG in microsurgery |
title_fullStr | First clinical applications for the NIR-II imaging with ICG in microsurgery |
title_full_unstemmed | First clinical applications for the NIR-II imaging with ICG in microsurgery |
title_short | First clinical applications for the NIR-II imaging with ICG in microsurgery |
title_sort | first clinical applications for the nir-ii imaging with icg in microsurgery |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623121/ https://www.ncbi.nlm.nih.gov/pubmed/36329697 http://dx.doi.org/10.3389/fbioe.2022.1042546 |
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