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First clinical applications for the NIR-II imaging with ICG in microsurgery

In microsurgery, it is always difficult to accurately identify the blood supply with ease, such as vascular anastomosis, digit replantation, skin avulsion reconstruction and flap transplantation. Near-infrared window I (NIR-I, 700—900 nm) imaging has many clinical applications, whereas near-infrared...

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Autores principales: Wu, Yifan, Suo, Yongkuan, Wang, Zheng, Yu, Yifeng, Duan, Shuang, Liu, Hongguang, Qi, Baiwen, Jian, Chao, Hu, Xiang, Zhang, Dong, Yu, Aixi, Cheng, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623121/
https://www.ncbi.nlm.nih.gov/pubmed/36329697
http://dx.doi.org/10.3389/fbioe.2022.1042546
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author Wu, Yifan
Suo, Yongkuan
Wang, Zheng
Yu, Yifeng
Duan, Shuang
Liu, Hongguang
Qi, Baiwen
Jian, Chao
Hu, Xiang
Zhang, Dong
Yu, Aixi
Cheng, Zhen
author_facet Wu, Yifan
Suo, Yongkuan
Wang, Zheng
Yu, Yifeng
Duan, Shuang
Liu, Hongguang
Qi, Baiwen
Jian, Chao
Hu, Xiang
Zhang, Dong
Yu, Aixi
Cheng, Zhen
author_sort Wu, Yifan
collection PubMed
description In microsurgery, it is always difficult to accurately identify the blood supply with ease, such as vascular anastomosis, digit replantation, skin avulsion reconstruction and flap transplantation. Near-infrared window I (NIR-I, 700—900 nm) imaging has many clinical applications, whereas near-infrared window II (NIR-II, 1,000–1700 nm) imaging has emerged as a highly promising novel optical imaging modality and used in a few clinical fields recently, especially its penetration distance and noninvasive characteristics coincide with the needs of microsurgery. Therefore, a portable NIR-II imaging instrument and the Food and Drug Administration (FDA) approved indocyanine green (ICG) were used to improve the operation efficiency in microsurgery of 39 patients in this study. The anastomotic vessels and the salvaged distal limbs were clearly visualized after intravenous injection of ICG. The technique enabled identification of perforator vessels and estimation of perforator areas prior to the flap obtention and made it easier to monitor the prognosis. Overall, this study highlights the use of the portable NIR- II imaging with ICG as an operative evaluation tool can enhance the safety and accuracy of microsurgery.
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spelling pubmed-96231212022-11-02 First clinical applications for the NIR-II imaging with ICG in microsurgery Wu, Yifan Suo, Yongkuan Wang, Zheng Yu, Yifeng Duan, Shuang Liu, Hongguang Qi, Baiwen Jian, Chao Hu, Xiang Zhang, Dong Yu, Aixi Cheng, Zhen Front Bioeng Biotechnol Bioengineering and Biotechnology In microsurgery, it is always difficult to accurately identify the blood supply with ease, such as vascular anastomosis, digit replantation, skin avulsion reconstruction and flap transplantation. Near-infrared window I (NIR-I, 700—900 nm) imaging has many clinical applications, whereas near-infrared window II (NIR-II, 1,000–1700 nm) imaging has emerged as a highly promising novel optical imaging modality and used in a few clinical fields recently, especially its penetration distance and noninvasive characteristics coincide with the needs of microsurgery. Therefore, a portable NIR-II imaging instrument and the Food and Drug Administration (FDA) approved indocyanine green (ICG) were used to improve the operation efficiency in microsurgery of 39 patients in this study. The anastomotic vessels and the salvaged distal limbs were clearly visualized after intravenous injection of ICG. The technique enabled identification of perforator vessels and estimation of perforator areas prior to the flap obtention and made it easier to monitor the prognosis. Overall, this study highlights the use of the portable NIR- II imaging with ICG as an operative evaluation tool can enhance the safety and accuracy of microsurgery. Frontiers Media S.A. 2022-10-18 /pmc/articles/PMC9623121/ /pubmed/36329697 http://dx.doi.org/10.3389/fbioe.2022.1042546 Text en Copyright © 2022 Wu, Suo, Wang, Yu, Duan, Liu, Qi, Jian, Hu, Zhang, Yu and Cheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Wu, Yifan
Suo, Yongkuan
Wang, Zheng
Yu, Yifeng
Duan, Shuang
Liu, Hongguang
Qi, Baiwen
Jian, Chao
Hu, Xiang
Zhang, Dong
Yu, Aixi
Cheng, Zhen
First clinical applications for the NIR-II imaging with ICG in microsurgery
title First clinical applications for the NIR-II imaging with ICG in microsurgery
title_full First clinical applications for the NIR-II imaging with ICG in microsurgery
title_fullStr First clinical applications for the NIR-II imaging with ICG in microsurgery
title_full_unstemmed First clinical applications for the NIR-II imaging with ICG in microsurgery
title_short First clinical applications for the NIR-II imaging with ICG in microsurgery
title_sort first clinical applications for the nir-ii imaging with icg in microsurgery
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623121/
https://www.ncbi.nlm.nih.gov/pubmed/36329697
http://dx.doi.org/10.3389/fbioe.2022.1042546
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