Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper

PURPOSE: We hypothesized that inhibition and trapping of PARP1 alone would be sufficient to achieve antitumor activity. In particular, we aimed to achieve selectivity over PARP2, which has been shown to play a role in the survival of hematopoietic/stem progenitor cells in animal models. We developed...

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Detalles Bibliográficos
Autores principales: Illuzzi, Giuditta, Staniszewska, Anna D., Gill, Sonja J., Pike, Andy, McWilliams, Lisa, Critchlow, Susan E., Cronin, Anna, Fawell, Stephen, Hawthorne, Glen, Jamal, Kunzah, Johannes, Jeffrey, Leonard, Emilyanne, Macdonald, Ruth, Maglennon, Gareth, Nikkilä, Jenni, O'Connor, Mark J., Smith, Aaron, Southgate, Harriet, Wilson, Joanne, Yates, James, Cosulich, Sabina, Leo, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623235/
https://www.ncbi.nlm.nih.gov/pubmed/35929986
http://dx.doi.org/10.1158/1078-0432.CCR-22-0301

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