Rb Tumor Suppressor in Small Cell Lung Cancer: Combined Genomic and IHC Analysis with a Description of a Distinct Rb-Proficient Subset

PURPOSE: RB1 mutations and loss of retinoblastoma (Rb) expression represent consistent but not entirely invariable hallmarks of small cell lung cancer (SCLC). The prevalence and characteristics of SCLC retaining wild-type Rb are not well-established. Furthermore, the performance of targeted next-gen...

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Detalles Bibliográficos
Autores principales: Febres-Aldana, Christopher A., Chang, Jason C., Ptashkin, Ryan, Wang, Yuhan, Gedvilaite, Erika, Baine, Marina K., Travis, William D., Ventura, Katia, Bodd, Francis, Yu, Helena A., Quintanal-Villalonga, Alvaro, Lai, W. Victoria, Egger, Jacklynn V., Offin, Michael, Ladanyi, Marc, Rudin, Charles M., Rekhtman, Natasha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623236/
https://www.ncbi.nlm.nih.gov/pubmed/35792876
http://dx.doi.org/10.1158/1078-0432.CCR-22-1115

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