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Tollip negatively regulates mitophagy by promoting the mitochondrial processing and cytoplasmic release of PINK1
PTEN-induced putative kinase 1 (PINK1) is a serine/threonine kinase that phosphorylates several substrates and exerts neuroprotective effects against stress-induced apoptotic cell death. Mutations in PINK1 have been linked to autosomal recessive forms of Parkinson’s disease (PD). Mitophagy is a type...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Korean Society for Biochemistry and Molecular Biology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623242/ https://www.ncbi.nlm.nih.gov/pubmed/35725015 http://dx.doi.org/10.5483/BMBRep.2022.55.10.082 |