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Mid-term subclinical myocardial injury detection in patients who recovered from COVID-19 according to pulmonary lesion severity

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) may cause damage to the cardiovascular system during the acute phase of the infection. However, recent studies reported mid- to long-term subtle cardiac injuries after recovering from acute coronavirus disease 2019 (COVID-19)....

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Autores principales: Chamtouri, Ikram, Kaddoussi, Rania, Abroug, Hela, Abdelaaly, Mabrouk, Lassoued, Taha, Fahem, Nesrine, Cheikh'Hmad, Saoussen, Ben Abdallah, Asma, Jomaa, Walid, Ben Hamda, Khaldoun, Maatouk, Faouzi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623290/
https://www.ncbi.nlm.nih.gov/pubmed/36330010
http://dx.doi.org/10.3389/fcvm.2022.950334
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author Chamtouri, Ikram
Kaddoussi, Rania
Abroug, Hela
Abdelaaly, Mabrouk
Lassoued, Taha
Fahem, Nesrine
Cheikh'Hmad, Saoussen
Ben Abdallah, Asma
Jomaa, Walid
Ben Hamda, Khaldoun
Maatouk, Faouzi
author_facet Chamtouri, Ikram
Kaddoussi, Rania
Abroug, Hela
Abdelaaly, Mabrouk
Lassoued, Taha
Fahem, Nesrine
Cheikh'Hmad, Saoussen
Ben Abdallah, Asma
Jomaa, Walid
Ben Hamda, Khaldoun
Maatouk, Faouzi
author_sort Chamtouri, Ikram
collection PubMed
description BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) may cause damage to the cardiovascular system during the acute phase of the infection. However, recent studies reported mid- to long-term subtle cardiac injuries after recovering from acute coronavirus disease 2019 (COVID-19). This study aimed to determine the relationship between the severity of chest computed tomography (CT) lesions and the persistence of subtle myocardial injuries at mid-term follow-up of patients who recovered from COVID-19 infection. METHODS: All patients with COVID-19 were enrolled prospectively in this study. Sensitive troponin T (hsTnT) and chest CT scans were performed on all patients during the acute phase of COVID-19 infection. At the mid-term follow-up, conventional transthoracic echocardiograph and global longitudinal strain (GLS) of the left and right ventricles (LV and RV) were determined and compared between patients with chest CT scan lesions of < 50% (Group 1) and those with severe chest CT scan lesions of greater or equal to 50% (Group 2). RESULTS: The mean age was 55 ± 14 years. Both LV GLS and RV GLS values were significantly decreased in group 2 (p = 0.013 and p = 0.011, respectively). LV GLS value of more than −18 was noted in 43% of all the patients, and an RV GLS value of more than −20 was observed in 48% of them. The group with severe chest CT scan lesions included more patients with reduced LV GLS and reduced RV GLS than the group with mild chest CT scan lesions [(G1:29 vs. G2:57%, p = 0.002) and (G1:36 vs. G2:60 %, p = 0.009), respectively]. CONCLUSION: Patients with severe chest CT scan lesions are more likely to develop subclinical myocardial damage. Transthoracic echocardiography (TTE) could be recommended in patients recovering from COVID-19 to detect subtle LV and RV lesions.
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spelling pubmed-96232902022-11-02 Mid-term subclinical myocardial injury detection in patients who recovered from COVID-19 according to pulmonary lesion severity Chamtouri, Ikram Kaddoussi, Rania Abroug, Hela Abdelaaly, Mabrouk Lassoued, Taha Fahem, Nesrine Cheikh'Hmad, Saoussen Ben Abdallah, Asma Jomaa, Walid Ben Hamda, Khaldoun Maatouk, Faouzi Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) may cause damage to the cardiovascular system during the acute phase of the infection. However, recent studies reported mid- to long-term subtle cardiac injuries after recovering from acute coronavirus disease 2019 (COVID-19). This study aimed to determine the relationship between the severity of chest computed tomography (CT) lesions and the persistence of subtle myocardial injuries at mid-term follow-up of patients who recovered from COVID-19 infection. METHODS: All patients with COVID-19 were enrolled prospectively in this study. Sensitive troponin T (hsTnT) and chest CT scans were performed on all patients during the acute phase of COVID-19 infection. At the mid-term follow-up, conventional transthoracic echocardiograph and global longitudinal strain (GLS) of the left and right ventricles (LV and RV) were determined and compared between patients with chest CT scan lesions of < 50% (Group 1) and those with severe chest CT scan lesions of greater or equal to 50% (Group 2). RESULTS: The mean age was 55 ± 14 years. Both LV GLS and RV GLS values were significantly decreased in group 2 (p = 0.013 and p = 0.011, respectively). LV GLS value of more than −18 was noted in 43% of all the patients, and an RV GLS value of more than −20 was observed in 48% of them. The group with severe chest CT scan lesions included more patients with reduced LV GLS and reduced RV GLS than the group with mild chest CT scan lesions [(G1:29 vs. G2:57%, p = 0.002) and (G1:36 vs. G2:60 %, p = 0.009), respectively]. CONCLUSION: Patients with severe chest CT scan lesions are more likely to develop subclinical myocardial damage. Transthoracic echocardiography (TTE) could be recommended in patients recovering from COVID-19 to detect subtle LV and RV lesions. Frontiers Media S.A. 2022-10-18 /pmc/articles/PMC9623290/ /pubmed/36330010 http://dx.doi.org/10.3389/fcvm.2022.950334 Text en Copyright © 2022 Chamtouri, Kaddoussi, Abroug, Abdelaaly, Lassoued, Fahem, Cheikh'Hmad, Ben Abdallah, Jomaa, Ben Hamda and Maatouk. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Chamtouri, Ikram
Kaddoussi, Rania
Abroug, Hela
Abdelaaly, Mabrouk
Lassoued, Taha
Fahem, Nesrine
Cheikh'Hmad, Saoussen
Ben Abdallah, Asma
Jomaa, Walid
Ben Hamda, Khaldoun
Maatouk, Faouzi
Mid-term subclinical myocardial injury detection in patients who recovered from COVID-19 according to pulmonary lesion severity
title Mid-term subclinical myocardial injury detection in patients who recovered from COVID-19 according to pulmonary lesion severity
title_full Mid-term subclinical myocardial injury detection in patients who recovered from COVID-19 according to pulmonary lesion severity
title_fullStr Mid-term subclinical myocardial injury detection in patients who recovered from COVID-19 according to pulmonary lesion severity
title_full_unstemmed Mid-term subclinical myocardial injury detection in patients who recovered from COVID-19 according to pulmonary lesion severity
title_short Mid-term subclinical myocardial injury detection in patients who recovered from COVID-19 according to pulmonary lesion severity
title_sort mid-term subclinical myocardial injury detection in patients who recovered from covid-19 according to pulmonary lesion severity
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623290/
https://www.ncbi.nlm.nih.gov/pubmed/36330010
http://dx.doi.org/10.3389/fcvm.2022.950334
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