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A spotlight on alkaloid nanoformulations for the treatment of lung cancer
Numerous naturally available phytochemicals have potential anti-cancer activities due to their vast structural diversity. Alkaloids have been extensively used in cancer treatment, especially lung cancers, among the plant-based compounds. However, their utilization is limited by their poor solubility...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623325/ https://www.ncbi.nlm.nih.gov/pubmed/36330493 http://dx.doi.org/10.3389/fonc.2022.994155 |
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author | S. M., Sindhoor Naveen, N. Raghavendra Rao, GSN Koteswara Gopan, Gopika Chopra, Hitesh Park, Moon Nyeo Alshahrani, Mohammed Merae Jose, Jobin Emran, Talha Bin Kim, Bonglee |
author_facet | S. M., Sindhoor Naveen, N. Raghavendra Rao, GSN Koteswara Gopan, Gopika Chopra, Hitesh Park, Moon Nyeo Alshahrani, Mohammed Merae Jose, Jobin Emran, Talha Bin Kim, Bonglee |
author_sort | S. M., Sindhoor |
collection | PubMed |
description | Numerous naturally available phytochemicals have potential anti-cancer activities due to their vast structural diversity. Alkaloids have been extensively used in cancer treatment, especially lung cancers, among the plant-based compounds. However, their utilization is limited by their poor solubility, low bioavailability, and inadequacies such as lack of specificity to cancer cells and indiscriminate distribution in the tissues. Incorporating the alkaloids into nanoformulations can overcome the said limitations paving the way for effective delivery of the alkaloids to the site of action in sufficient concentrations, which is crucial in tumor targeting. Our review attempts to assess whether alkaloid nanoformulation can be an effective tool in lung cancer therapy. The mechanism of action of each alkaloid having potential is explored in great detail in the review. In general, Alkaloids suppress oncogenesis by modulating several signaling pathways involved in multiplication, cell cycle, and metastasis, making them significant component of many clinical anti-cancerous agents. The review also explores the future prospects of alkaloid nanoformulation in lung cancer. So, in conclusion, alkaloid based nanoformulation will emerge as a potential gamechanger in treating lung cancer in the near future. |
format | Online Article Text |
id | pubmed-9623325 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96233252022-11-02 A spotlight on alkaloid nanoformulations for the treatment of lung cancer S. M., Sindhoor Naveen, N. Raghavendra Rao, GSN Koteswara Gopan, Gopika Chopra, Hitesh Park, Moon Nyeo Alshahrani, Mohammed Merae Jose, Jobin Emran, Talha Bin Kim, Bonglee Front Oncol Oncology Numerous naturally available phytochemicals have potential anti-cancer activities due to their vast structural diversity. Alkaloids have been extensively used in cancer treatment, especially lung cancers, among the plant-based compounds. However, their utilization is limited by their poor solubility, low bioavailability, and inadequacies such as lack of specificity to cancer cells and indiscriminate distribution in the tissues. Incorporating the alkaloids into nanoformulations can overcome the said limitations paving the way for effective delivery of the alkaloids to the site of action in sufficient concentrations, which is crucial in tumor targeting. Our review attempts to assess whether alkaloid nanoformulation can be an effective tool in lung cancer therapy. The mechanism of action of each alkaloid having potential is explored in great detail in the review. In general, Alkaloids suppress oncogenesis by modulating several signaling pathways involved in multiplication, cell cycle, and metastasis, making them significant component of many clinical anti-cancerous agents. The review also explores the future prospects of alkaloid nanoformulation in lung cancer. So, in conclusion, alkaloid based nanoformulation will emerge as a potential gamechanger in treating lung cancer in the near future. Frontiers Media S.A. 2022-10-18 /pmc/articles/PMC9623325/ /pubmed/36330493 http://dx.doi.org/10.3389/fonc.2022.994155 Text en Copyright © 2022 S. M., Naveen, Rao, Gopan, Chopra, Park, Alshahrani, Jose, Emran and Kim https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology S. M., Sindhoor Naveen, N. Raghavendra Rao, GSN Koteswara Gopan, Gopika Chopra, Hitesh Park, Moon Nyeo Alshahrani, Mohammed Merae Jose, Jobin Emran, Talha Bin Kim, Bonglee A spotlight on alkaloid nanoformulations for the treatment of lung cancer |
title | A spotlight on alkaloid nanoformulations for the treatment of lung cancer |
title_full | A spotlight on alkaloid nanoformulations for the treatment of lung cancer |
title_fullStr | A spotlight on alkaloid nanoformulations for the treatment of lung cancer |
title_full_unstemmed | A spotlight on alkaloid nanoformulations for the treatment of lung cancer |
title_short | A spotlight on alkaloid nanoformulations for the treatment of lung cancer |
title_sort | spotlight on alkaloid nanoformulations for the treatment of lung cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623325/ https://www.ncbi.nlm.nih.gov/pubmed/36330493 http://dx.doi.org/10.3389/fonc.2022.994155 |
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