A novel family of small molecule HIF-1 alpha stabilizers for the treatment of diabetic wounds; an integrated in silico, in vitro, and in vivo strategy

Hypoxia-inducible factor-1 alpha (HIF-1α) is a crucial regulator of wound healing, which includes epithelialization, angiogenesis, granulation, tissue development, and wound contraction. Even though diabetic wounds are hypoxic, HIF-1α levels are decreased during healing. Diabetic wound healing neces...

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Detalles Bibliográficos
Autores principales: M., Esakkimuthukumar, Swaroop, Akey Krishna, Patnaik, Sunil Kumar, Kumar R., Rajesh, T. K., Praveen, Naik, Mudavath Ravi, S., Jubie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623456/
https://www.ncbi.nlm.nih.gov/pubmed/36349012
http://dx.doi.org/10.1039/d2ra05364k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623456/
https://www.ncbi.nlm.nih.gov/pubmed/36349012
http://dx.doi.org/10.1039/d2ra05364k

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