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Time in range assessed by capillary blood glucose in relation to insulin sensitivity and β‐cell function in patients with type 2 diabetes mellitus: A cross‐sectional study in China

AIMS: This study investigated the association of capillary blood glucose (CBG)‐assessed time in range (TIR) (3.9–10.0 mmol/L) with insulin sensitivity and islet β‐cell function. MATERIALS AND METHODS: We recruited 455 patients with type 2 diabetes mellitus. Seven‐point glucose‐profile data (pre‐ and...

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Autores principales: Ye, Jingwen, Deng, Jiajin, Liang, Weiqiang, Luo, Haizhao, Mei, Wen, Liu, Lei, Wang, Mingzhu, Shu, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623508/
https://www.ncbi.nlm.nih.gov/pubmed/35739637
http://dx.doi.org/10.1111/jdi.13876
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author Ye, Jingwen
Deng, Jiajin
Liang, Weiqiang
Luo, Haizhao
Mei, Wen
Liu, Lei
Wang, Mingzhu
Shu, Yi
author_facet Ye, Jingwen
Deng, Jiajin
Liang, Weiqiang
Luo, Haizhao
Mei, Wen
Liu, Lei
Wang, Mingzhu
Shu, Yi
author_sort Ye, Jingwen
collection PubMed
description AIMS: This study investigated the association of capillary blood glucose (CBG)‐assessed time in range (TIR) (3.9–10.0 mmol/L) with insulin sensitivity and islet β‐cell function. MATERIALS AND METHODS: We recruited 455 patients with type 2 diabetes mellitus. Seven‐point glucose‐profile data (pre‐ and 120 min post‐main meals, bedtime) were collected over three consecutive days. Plasma glucose and serum insulin concentrations were measured at 0, 60, and 120 min after a 100 g standard steamed bread meal test. The homeostasis model assessment of insulin resistance (HOMA‐IR) and Matsuda index were computed to evaluate insulin resistance. The HOMA of β‐cell function (HOMA‐β) and the area under the curve between insulin and blood glucose (IAUC(0−120)/GAUC(0−120)) were used to estimate β‐cell function. RESULTS: TIR was positively correlated with the 60 and 120 min insulin values, IAUC(0−120), the Matsuda index, HOMA‐β, and IAUC(0−120)/GAUC(0−120) (r (s): 0.154, 0.129, 0.137, 0.194, 0.341, and 0.334, respectively; P < 0.05) but inversely correlated with HOMA‐IR (r (s): –0.239, P < 0.001). After adjusting for confounders, multinomial multiple logistic regression analysis revealed that the odds ratios (ORs) of achieving the target time in range (>70%) increased by 12% (95% confidence interval [CI]: 3–21%), 7% (95% CI: 1–14%), 10% (95% CI: 5–16%), and 45% (95% CI: 25–68%) for each 10 mIU/L increase in the 60 and 120 min insulin values, 10 unit increase in HOMA‐β, and unit increase in IAUC(0−120)/GAUC(0−120), respectively (P < 0.05). Nevertheless, the OR decreased by 10% (95% CI: 1–18%) for each unit increase in HOMA‐IR (P < 0.05). CONCLUSIONS: Insulin resistance and islet β‐cell function are related to capillary blood glucose‐assessed TIR.
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spelling pubmed-96235082022-11-02 Time in range assessed by capillary blood glucose in relation to insulin sensitivity and β‐cell function in patients with type 2 diabetes mellitus: A cross‐sectional study in China Ye, Jingwen Deng, Jiajin Liang, Weiqiang Luo, Haizhao Mei, Wen Liu, Lei Wang, Mingzhu Shu, Yi J Diabetes Investig Articles AIMS: This study investigated the association of capillary blood glucose (CBG)‐assessed time in range (TIR) (3.9–10.0 mmol/L) with insulin sensitivity and islet β‐cell function. MATERIALS AND METHODS: We recruited 455 patients with type 2 diabetes mellitus. Seven‐point glucose‐profile data (pre‐ and 120 min post‐main meals, bedtime) were collected over three consecutive days. Plasma glucose and serum insulin concentrations were measured at 0, 60, and 120 min after a 100 g standard steamed bread meal test. The homeostasis model assessment of insulin resistance (HOMA‐IR) and Matsuda index were computed to evaluate insulin resistance. The HOMA of β‐cell function (HOMA‐β) and the area under the curve between insulin and blood glucose (IAUC(0−120)/GAUC(0−120)) were used to estimate β‐cell function. RESULTS: TIR was positively correlated with the 60 and 120 min insulin values, IAUC(0−120), the Matsuda index, HOMA‐β, and IAUC(0−120)/GAUC(0−120) (r (s): 0.154, 0.129, 0.137, 0.194, 0.341, and 0.334, respectively; P < 0.05) but inversely correlated with HOMA‐IR (r (s): –0.239, P < 0.001). After adjusting for confounders, multinomial multiple logistic regression analysis revealed that the odds ratios (ORs) of achieving the target time in range (>70%) increased by 12% (95% confidence interval [CI]: 3–21%), 7% (95% CI: 1–14%), 10% (95% CI: 5–16%), and 45% (95% CI: 25–68%) for each 10 mIU/L increase in the 60 and 120 min insulin values, 10 unit increase in HOMA‐β, and unit increase in IAUC(0−120)/GAUC(0−120), respectively (P < 0.05). Nevertheless, the OR decreased by 10% (95% CI: 1–18%) for each unit increase in HOMA‐IR (P < 0.05). CONCLUSIONS: Insulin resistance and islet β‐cell function are related to capillary blood glucose‐assessed TIR. John Wiley and Sons Inc. 2022-07-11 2022-11 /pmc/articles/PMC9623508/ /pubmed/35739637 http://dx.doi.org/10.1111/jdi.13876 Text en © 2022 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Articles
Ye, Jingwen
Deng, Jiajin
Liang, Weiqiang
Luo, Haizhao
Mei, Wen
Liu, Lei
Wang, Mingzhu
Shu, Yi
Time in range assessed by capillary blood glucose in relation to insulin sensitivity and β‐cell function in patients with type 2 diabetes mellitus: A cross‐sectional study in China
title Time in range assessed by capillary blood glucose in relation to insulin sensitivity and β‐cell function in patients with type 2 diabetes mellitus: A cross‐sectional study in China
title_full Time in range assessed by capillary blood glucose in relation to insulin sensitivity and β‐cell function in patients with type 2 diabetes mellitus: A cross‐sectional study in China
title_fullStr Time in range assessed by capillary blood glucose in relation to insulin sensitivity and β‐cell function in patients with type 2 diabetes mellitus: A cross‐sectional study in China
title_full_unstemmed Time in range assessed by capillary blood glucose in relation to insulin sensitivity and β‐cell function in patients with type 2 diabetes mellitus: A cross‐sectional study in China
title_short Time in range assessed by capillary blood glucose in relation to insulin sensitivity and β‐cell function in patients with type 2 diabetes mellitus: A cross‐sectional study in China
title_sort time in range assessed by capillary blood glucose in relation to insulin sensitivity and β‐cell function in patients with type 2 diabetes mellitus: a cross‐sectional study in china
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623508/
https://www.ncbi.nlm.nih.gov/pubmed/35739637
http://dx.doi.org/10.1111/jdi.13876
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