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Effect of diabetes and prediabetes on the development of disability and mortality among middle‐aged Japanese adults: A 22‐year follow up of NIPPON DATA90

AIMS/INTRODUCTION: To examine the association between diabetes and prediabetes at baseline, and disability, mortality over a 22‐year period among middle‐aged Japanese adults. MATERIALS AND METHODS: Participants consisted of 1,788 adults aged 45–64 years at baseline from the cohort study National Int...

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Autores principales: Tran Ngoc Hoang, Phap, Kadota, Aya, Yano, Yuichiro, Harada, Akiko, Hayakawa, Takehito, Okamoto, Shohei, Miyagawa, Naoko, Kondo, Keiko, Okukda, Nagako, Kita, Yoshiuni, Okayama, Akira, Fujita, Yukihiro, Maegawa, Hiroshi, Miura, Katsuyuki, Okamura, Tomonori, Ueshima, Hirotsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623524/
https://www.ncbi.nlm.nih.gov/pubmed/35717665
http://dx.doi.org/10.1111/jdi.13871
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author Tran Ngoc Hoang, Phap
Kadota, Aya
Yano, Yuichiro
Harada, Akiko
Hayakawa, Takehito
Okamoto, Shohei
Miyagawa, Naoko
Kondo, Keiko
Okukda, Nagako
Kita, Yoshiuni
Okayama, Akira
Fujita, Yukihiro
Maegawa, Hiroshi
Miura, Katsuyuki
Okamura, Tomonori
Ueshima, Hirotsugu
author_facet Tran Ngoc Hoang, Phap
Kadota, Aya
Yano, Yuichiro
Harada, Akiko
Hayakawa, Takehito
Okamoto, Shohei
Miyagawa, Naoko
Kondo, Keiko
Okukda, Nagako
Kita, Yoshiuni
Okayama, Akira
Fujita, Yukihiro
Maegawa, Hiroshi
Miura, Katsuyuki
Okamura, Tomonori
Ueshima, Hirotsugu
author_sort Tran Ngoc Hoang, Phap
collection PubMed
description AIMS/INTRODUCTION: To examine the association between diabetes and prediabetes at baseline, and disability, mortality over a 22‐year period among middle‐aged Japanese adults. MATERIALS AND METHODS: Participants consisted of 1,788 adults aged 45–64 years at baseline from the cohort study National Integrated Project for Prospective Observation of Non‐communicable Disease and its Trends in the Aged 1990 (NIPPON DATA90). Disability, defined as having a decline in activities of daily living (ADL), was assessed by a modified Katz questionnaire at four time points. Disability and death without disability for 22‐year follow up were used as outcomes to test the association with a diagnosis of diabetes or prediabetes at baseline, using multinomial logistic regression. Adjusted odds ratios (ORs) were obtained from four models that contained appropriate adjustment factors, such as age, sex, smoking status, drinking status, body mass index and cardiovascular risk factors (hypertension, hypercholesterolemia, triglycerides, low serum high‐density lipoprotein), at baseline. RESULTS: In the present study, 334 participants (18.7%) reported at least one disability, and 350 (19.6%) were reported dead without observation of disability during follow up. Adjusting sex and other risk factors, participants with diabetes and prediabetes had a higher risk for disability (OR 1.43, 95% confidence interval [CI] 1.07–1.91 and OR 1.66, 95% CI 1.10–2.50, respectively) and for mortality (OR 1.56, 95% CI 1.16–2.08 and OR 1.77, 95% CI 1.18–2.65, respectively) than individuals with normal glucose tolerance. CONCLUSIONS: In middle‐aged Japanese adults, individuals with diabetes and prediabetes were more likely to be associated with disability and mortality. Our findings suggest that prediabetes and diabetes in middle‐aged adults should be paid more attention, and requires more intervention to prevent disability and mortality in later life.
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spelling pubmed-96235242022-11-02 Effect of diabetes and prediabetes on the development of disability and mortality among middle‐aged Japanese adults: A 22‐year follow up of NIPPON DATA90 Tran Ngoc Hoang, Phap Kadota, Aya Yano, Yuichiro Harada, Akiko Hayakawa, Takehito Okamoto, Shohei Miyagawa, Naoko Kondo, Keiko Okukda, Nagako Kita, Yoshiuni Okayama, Akira Fujita, Yukihiro Maegawa, Hiroshi Miura, Katsuyuki Okamura, Tomonori Ueshima, Hirotsugu J Diabetes Investig Articles AIMS/INTRODUCTION: To examine the association between diabetes and prediabetes at baseline, and disability, mortality over a 22‐year period among middle‐aged Japanese adults. MATERIALS AND METHODS: Participants consisted of 1,788 adults aged 45–64 years at baseline from the cohort study National Integrated Project for Prospective Observation of Non‐communicable Disease and its Trends in the Aged 1990 (NIPPON DATA90). Disability, defined as having a decline in activities of daily living (ADL), was assessed by a modified Katz questionnaire at four time points. Disability and death without disability for 22‐year follow up were used as outcomes to test the association with a diagnosis of diabetes or prediabetes at baseline, using multinomial logistic regression. Adjusted odds ratios (ORs) were obtained from four models that contained appropriate adjustment factors, such as age, sex, smoking status, drinking status, body mass index and cardiovascular risk factors (hypertension, hypercholesterolemia, triglycerides, low serum high‐density lipoprotein), at baseline. RESULTS: In the present study, 334 participants (18.7%) reported at least one disability, and 350 (19.6%) were reported dead without observation of disability during follow up. Adjusting sex and other risk factors, participants with diabetes and prediabetes had a higher risk for disability (OR 1.43, 95% confidence interval [CI] 1.07–1.91 and OR 1.66, 95% CI 1.10–2.50, respectively) and for mortality (OR 1.56, 95% CI 1.16–2.08 and OR 1.77, 95% CI 1.18–2.65, respectively) than individuals with normal glucose tolerance. CONCLUSIONS: In middle‐aged Japanese adults, individuals with diabetes and prediabetes were more likely to be associated with disability and mortality. Our findings suggest that prediabetes and diabetes in middle‐aged adults should be paid more attention, and requires more intervention to prevent disability and mortality in later life. John Wiley and Sons Inc. 2022-07-21 2022-11 /pmc/articles/PMC9623524/ /pubmed/35717665 http://dx.doi.org/10.1111/jdi.13871 Text en © 2022 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Articles
Tran Ngoc Hoang, Phap
Kadota, Aya
Yano, Yuichiro
Harada, Akiko
Hayakawa, Takehito
Okamoto, Shohei
Miyagawa, Naoko
Kondo, Keiko
Okukda, Nagako
Kita, Yoshiuni
Okayama, Akira
Fujita, Yukihiro
Maegawa, Hiroshi
Miura, Katsuyuki
Okamura, Tomonori
Ueshima, Hirotsugu
Effect of diabetes and prediabetes on the development of disability and mortality among middle‐aged Japanese adults: A 22‐year follow up of NIPPON DATA90
title Effect of diabetes and prediabetes on the development of disability and mortality among middle‐aged Japanese adults: A 22‐year follow up of NIPPON DATA90
title_full Effect of diabetes and prediabetes on the development of disability and mortality among middle‐aged Japanese adults: A 22‐year follow up of NIPPON DATA90
title_fullStr Effect of diabetes and prediabetes on the development of disability and mortality among middle‐aged Japanese adults: A 22‐year follow up of NIPPON DATA90
title_full_unstemmed Effect of diabetes and prediabetes on the development of disability and mortality among middle‐aged Japanese adults: A 22‐year follow up of NIPPON DATA90
title_short Effect of diabetes and prediabetes on the development of disability and mortality among middle‐aged Japanese adults: A 22‐year follow up of NIPPON DATA90
title_sort effect of diabetes and prediabetes on the development of disability and mortality among middle‐aged japanese adults: a 22‐year follow up of nippon data90
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623524/
https://www.ncbi.nlm.nih.gov/pubmed/35717665
http://dx.doi.org/10.1111/jdi.13871
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