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Oral fat tolerance testing identifies abnormal pancreatic β‐cell function and insulin resistance in individuals with normal glucose tolerance
AIMS/INTRODUCTION: Insulin sensitivity and β‐cell function are affected by lipid metabolism disorders, even before the onset of type 2 diabetes. People are in the postprandial state most of the time. Therefore, identifying postprandial hyperlipemia is important. This study aimed to assess patients w...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623526/ https://www.ncbi.nlm.nih.gov/pubmed/35678496 http://dx.doi.org/10.1111/jdi.13867 |
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author | Liu, Lifang Hou, Xiaoyu Song, An Guan, Yunpeng Tian, Peipei Wang, Chao Ren, Luping Tang, Yong Gao, Ling Xing, Xiaoping Song, Guangyao |
author_facet | Liu, Lifang Hou, Xiaoyu Song, An Guan, Yunpeng Tian, Peipei Wang, Chao Ren, Luping Tang, Yong Gao, Ling Xing, Xiaoping Song, Guangyao |
author_sort | Liu, Lifang |
collection | PubMed |
description | AIMS/INTRODUCTION: Insulin sensitivity and β‐cell function are affected by lipid metabolism disorders, even before the onset of type 2 diabetes. People are in the postprandial state most of the time. Therefore, identifying postprandial hyperlipemia is important. This study aimed to assess patients with abnormalities in lipid metabolism, but with normal glucose tolerance, using oral fat tolerance testing (OFTT) to identify defects in insulin sensitivity and β‐cell function. MATERIALS AND METHODS: We included 248 volunteers with normal glucose tolerance who underwent OFTT. They were divided into three groups in accordance with their fasting and 4‐h postprandial triglyceride (TG) concentrations. Their lipid concentrations during OFTT were compared. The disposition index (DI) was applied to estimate β‐cell function, and the Matsuda insulin sensitivity index (ISI(M)) was used to assess insulin sensitivity. We used multiple linear regression analysis to estimate the relationships of fasting and postprandial TG concentrations with β‐cell function and insulin sensitivity . RESULTS: The changes in TG concentrations during OFTT were more marked than those in low‐density lipoprotein‐cholesterol, high‐density lipoprotein‐cholesterol or total cholesterol concentrations. As lipid metabolism deteriorated, the ISI(M) and the DI gradually decreased. Multiple linear regression analysis showed that fasting and 4‐h postprandial TG concentrations affected LnISI(M) and LnDI. CONCLUSIONS: In individuals with normal glucose tolerance, β‐cell function and insulin sensitivity gradually decrease with a deterioration in the lipid profile. Not only fasting TG, but also postprandial TG concentrations are independent risk factors for impaired β‐cell function and insulin resistance. |
format | Online Article Text |
id | pubmed-9623526 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96235262022-11-02 Oral fat tolerance testing identifies abnormal pancreatic β‐cell function and insulin resistance in individuals with normal glucose tolerance Liu, Lifang Hou, Xiaoyu Song, An Guan, Yunpeng Tian, Peipei Wang, Chao Ren, Luping Tang, Yong Gao, Ling Xing, Xiaoping Song, Guangyao J Diabetes Investig Articles AIMS/INTRODUCTION: Insulin sensitivity and β‐cell function are affected by lipid metabolism disorders, even before the onset of type 2 diabetes. People are in the postprandial state most of the time. Therefore, identifying postprandial hyperlipemia is important. This study aimed to assess patients with abnormalities in lipid metabolism, but with normal glucose tolerance, using oral fat tolerance testing (OFTT) to identify defects in insulin sensitivity and β‐cell function. MATERIALS AND METHODS: We included 248 volunteers with normal glucose tolerance who underwent OFTT. They were divided into three groups in accordance with their fasting and 4‐h postprandial triglyceride (TG) concentrations. Their lipid concentrations during OFTT were compared. The disposition index (DI) was applied to estimate β‐cell function, and the Matsuda insulin sensitivity index (ISI(M)) was used to assess insulin sensitivity. We used multiple linear regression analysis to estimate the relationships of fasting and postprandial TG concentrations with β‐cell function and insulin sensitivity . RESULTS: The changes in TG concentrations during OFTT were more marked than those in low‐density lipoprotein‐cholesterol, high‐density lipoprotein‐cholesterol or total cholesterol concentrations. As lipid metabolism deteriorated, the ISI(M) and the DI gradually decreased. Multiple linear regression analysis showed that fasting and 4‐h postprandial TG concentrations affected LnISI(M) and LnDI. CONCLUSIONS: In individuals with normal glucose tolerance, β‐cell function and insulin sensitivity gradually decrease with a deterioration in the lipid profile. Not only fasting TG, but also postprandial TG concentrations are independent risk factors for impaired β‐cell function and insulin resistance. John Wiley and Sons Inc. 2022-06-27 2022-11 /pmc/articles/PMC9623526/ /pubmed/35678496 http://dx.doi.org/10.1111/jdi.13867 Text en © 2022 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Articles Liu, Lifang Hou, Xiaoyu Song, An Guan, Yunpeng Tian, Peipei Wang, Chao Ren, Luping Tang, Yong Gao, Ling Xing, Xiaoping Song, Guangyao Oral fat tolerance testing identifies abnormal pancreatic β‐cell function and insulin resistance in individuals with normal glucose tolerance |
title | Oral fat tolerance testing identifies abnormal pancreatic β‐cell function and insulin resistance in individuals with normal glucose tolerance |
title_full | Oral fat tolerance testing identifies abnormal pancreatic β‐cell function and insulin resistance in individuals with normal glucose tolerance |
title_fullStr | Oral fat tolerance testing identifies abnormal pancreatic β‐cell function and insulin resistance in individuals with normal glucose tolerance |
title_full_unstemmed | Oral fat tolerance testing identifies abnormal pancreatic β‐cell function and insulin resistance in individuals with normal glucose tolerance |
title_short | Oral fat tolerance testing identifies abnormal pancreatic β‐cell function and insulin resistance in individuals with normal glucose tolerance |
title_sort | oral fat tolerance testing identifies abnormal pancreatic β‐cell function and insulin resistance in individuals with normal glucose tolerance |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623526/ https://www.ncbi.nlm.nih.gov/pubmed/35678496 http://dx.doi.org/10.1111/jdi.13867 |
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