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ATP levels influence cell movement during the mound phase in Dictyostelium discoideum as revealed by ATP visualization and simulation
Cell migration plays an important role in multicellular organism development. The cellular slime mold Dictyostelium discoideum is a useful model organism for the study of cell migration during development. Although cellular ATP levels are known to determine cell fate during development, the underlyi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623536/ https://www.ncbi.nlm.nih.gov/pubmed/36054629 http://dx.doi.org/10.1002/2211-5463.13480 |
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author | Hiraoka, Haruka Wang, Jiewen Nakano, Tadashi Hirano, Yasuhiro Yamazaki, Shinichi Hiraoka, Yasushi Haraguchi, Tokuko |
author_facet | Hiraoka, Haruka Wang, Jiewen Nakano, Tadashi Hirano, Yasuhiro Yamazaki, Shinichi Hiraoka, Yasushi Haraguchi, Tokuko |
author_sort | Hiraoka, Haruka |
collection | PubMed |
description | Cell migration plays an important role in multicellular organism development. The cellular slime mold Dictyostelium discoideum is a useful model organism for the study of cell migration during development. Although cellular ATP levels are known to determine cell fate during development, the underlying mechanism remains unclear. Here, we report that ATP‐rich cells efficiently move to the central tip region of the mound against rotational movement during the mound phase. A simulation analysis based on an agent‐based model reproduces the movement of ATP‐rich cells observed in the experiments. These findings indicate that ATP‐rich cells have the ability to move against the bulk flow of cells, suggesting a mechanism by which high ATP levels determine the cell fate of differentiation. |
format | Online Article Text |
id | pubmed-9623536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96235362022-11-02 ATP levels influence cell movement during the mound phase in Dictyostelium discoideum as revealed by ATP visualization and simulation Hiraoka, Haruka Wang, Jiewen Nakano, Tadashi Hirano, Yasuhiro Yamazaki, Shinichi Hiraoka, Yasushi Haraguchi, Tokuko FEBS Open Bio Research Articles Cell migration plays an important role in multicellular organism development. The cellular slime mold Dictyostelium discoideum is a useful model organism for the study of cell migration during development. Although cellular ATP levels are known to determine cell fate during development, the underlying mechanism remains unclear. Here, we report that ATP‐rich cells efficiently move to the central tip region of the mound against rotational movement during the mound phase. A simulation analysis based on an agent‐based model reproduces the movement of ATP‐rich cells observed in the experiments. These findings indicate that ATP‐rich cells have the ability to move against the bulk flow of cells, suggesting a mechanism by which high ATP levels determine the cell fate of differentiation. John Wiley and Sons Inc. 2022-09-23 /pmc/articles/PMC9623536/ /pubmed/36054629 http://dx.doi.org/10.1002/2211-5463.13480 Text en © 2022 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Hiraoka, Haruka Wang, Jiewen Nakano, Tadashi Hirano, Yasuhiro Yamazaki, Shinichi Hiraoka, Yasushi Haraguchi, Tokuko ATP levels influence cell movement during the mound phase in Dictyostelium discoideum as revealed by ATP visualization and simulation |
title |
ATP levels influence cell movement during the mound phase in Dictyostelium discoideum as revealed by ATP visualization and simulation |
title_full |
ATP levels influence cell movement during the mound phase in Dictyostelium discoideum as revealed by ATP visualization and simulation |
title_fullStr |
ATP levels influence cell movement during the mound phase in Dictyostelium discoideum as revealed by ATP visualization and simulation |
title_full_unstemmed |
ATP levels influence cell movement during the mound phase in Dictyostelium discoideum as revealed by ATP visualization and simulation |
title_short |
ATP levels influence cell movement during the mound phase in Dictyostelium discoideum as revealed by ATP visualization and simulation |
title_sort | atp levels influence cell movement during the mound phase in dictyostelium discoideum as revealed by atp visualization and simulation |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623536/ https://www.ncbi.nlm.nih.gov/pubmed/36054629 http://dx.doi.org/10.1002/2211-5463.13480 |
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