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Systems Immunology Analyses of STAT1 Gain-of-Function Immune Phenotypes Reveal Heterogeneous Response to IL-6 and Broad Immunometabolic Roles for STAT1

Patients with STAT1 gain-of-function (GOF) pathogenic variants have enhanced or prolonged STAT1 phosphorylation following cytokine stimulation and exhibit increased yet heterogeneous susceptibility to infections, autoimmunity, and cancer. Although disease phenotypes are diverse and other genetic fac...

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Detalles Bibliográficos
Autores principales:	Kaviany, Saara, Bartkowiak, Todd, Dulek, Daniel E., Khan, Yasmin W., Hayes, Madeline J., Schaefer, Samuel G., Ye, Xiang, Dahunsi, Debolanle O., Connelly, James A., Irish, Jonathan M., Rathmell, Jeffrey C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623573/ https://www.ncbi.nlm.nih.gov/pubmed/35840326 http://dx.doi.org/10.4049/immunohorizons.2200041

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