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Effects of oral white willow bark (Salix alba) and intravenous flunixin meglumine on prostaglandin E(2) in healthy dairy calves

White willow bark (WWB) is commonly used in combination with other medicinal herbs and analgesics to alleviate inflammatory pain in disbudded calves under organic management, but there is no evidence to confirm an effect of WWB on inflammatory biomarkers in calves. The objective of this study was to...

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Autores principales: Phillips, H.N., Sharpe, K.T., Endres, M.I., Heins, B.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623693/
https://www.ncbi.nlm.nih.gov/pubmed/36340684
http://dx.doi.org/10.3168/jdsc.2021-0138
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author Phillips, H.N.
Sharpe, K.T.
Endres, M.I.
Heins, B.J.
author_facet Phillips, H.N.
Sharpe, K.T.
Endres, M.I.
Heins, B.J.
author_sort Phillips, H.N.
collection PubMed
description White willow bark (WWB) is commonly used in combination with other medicinal herbs and analgesics to alleviate inflammatory pain in disbudded calves under organic management, but there is no evidence to confirm an effect of WWB on inflammatory biomarkers in calves. The objective of this study was to determine whether WWB affects the inflammatory biomarker prostaglandin E(2) (PGE(2)) in healthy dairy calves. A randomized crossover trial with 2 periods and 5 treatments was used for this experiment. A 7-d washout period was used to minimize carryover effects. The treatments were (1) 57.6 mg/kg oral WWB (low dose; L-WWB), (2) 115.1 mg/kg oral WWB (medium dose; M-WWB), (3) 230.3 mg/kg oral WWB (high dose; H-WWB), (4) 2.2 mg/kg i.v. flunixin meglumine (FM), or (5) no treatment (NT). Calves (n = 25) were randomly assigned to receive 1 of the 25 treatment sequences. Blood samples were collected at 1, 2, and 4 h after administration to determine PGE(2) and salicylic acid plasma concentrations. The WWB had 2,171 μg/g (± 4.3% relative standard error) salicin (0.22%). On average, calves in the FM (721 ± 274 pg/mL) treatment had lower PGE(2) than calves in all other treatments. Calves in the NT (2,606 ± 271 pg/mL), L-WWB (2,509 ± 276 pg/mL), M-WWB (2,343 ± 270 pg/mL), and H-WWB (3,039 ± 270 pg/mL) treatments had similar PGE(2) averaged across sampling times. Calves in the L-WWB (23.4 ± 1.9 ng/mL), M-WWB (21.5 ± 1.9 ng/mL), and H-WWB (23.3 ± 1.9 ng/mL) treatments had similar maximum salicylic acid plasma concentrations. Results from this study indicate that the WWB doses used in this experiment were ineffective at achieving dose-dependent PGE(2) and salicylic acid plasma concentration responses.
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spelling pubmed-96236932022-11-04 Effects of oral white willow bark (Salix alba) and intravenous flunixin meglumine on prostaglandin E(2) in healthy dairy calves Phillips, H.N. Sharpe, K.T. Endres, M.I. Heins, B.J. JDS Commun Health, Behavior, and Well-being White willow bark (WWB) is commonly used in combination with other medicinal herbs and analgesics to alleviate inflammatory pain in disbudded calves under organic management, but there is no evidence to confirm an effect of WWB on inflammatory biomarkers in calves. The objective of this study was to determine whether WWB affects the inflammatory biomarker prostaglandin E(2) (PGE(2)) in healthy dairy calves. A randomized crossover trial with 2 periods and 5 treatments was used for this experiment. A 7-d washout period was used to minimize carryover effects. The treatments were (1) 57.6 mg/kg oral WWB (low dose; L-WWB), (2) 115.1 mg/kg oral WWB (medium dose; M-WWB), (3) 230.3 mg/kg oral WWB (high dose; H-WWB), (4) 2.2 mg/kg i.v. flunixin meglumine (FM), or (5) no treatment (NT). Calves (n = 25) were randomly assigned to receive 1 of the 25 treatment sequences. Blood samples were collected at 1, 2, and 4 h after administration to determine PGE(2) and salicylic acid plasma concentrations. The WWB had 2,171 μg/g (± 4.3% relative standard error) salicin (0.22%). On average, calves in the FM (721 ± 274 pg/mL) treatment had lower PGE(2) than calves in all other treatments. Calves in the NT (2,606 ± 271 pg/mL), L-WWB (2,509 ± 276 pg/mL), M-WWB (2,343 ± 270 pg/mL), and H-WWB (3,039 ± 270 pg/mL) treatments had similar PGE(2) averaged across sampling times. Calves in the L-WWB (23.4 ± 1.9 ng/mL), M-WWB (21.5 ± 1.9 ng/mL), and H-WWB (23.3 ± 1.9 ng/mL) treatments had similar maximum salicylic acid plasma concentrations. Results from this study indicate that the WWB doses used in this experiment were ineffective at achieving dose-dependent PGE(2) and salicylic acid plasma concentration responses. Elsevier 2021-10-22 /pmc/articles/PMC9623693/ /pubmed/36340684 http://dx.doi.org/10.3168/jdsc.2021-0138 Text en © 2021. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Health, Behavior, and Well-being
Phillips, H.N.
Sharpe, K.T.
Endres, M.I.
Heins, B.J.
Effects of oral white willow bark (Salix alba) and intravenous flunixin meglumine on prostaglandin E(2) in healthy dairy calves
title Effects of oral white willow bark (Salix alba) and intravenous flunixin meglumine on prostaglandin E(2) in healthy dairy calves
title_full Effects of oral white willow bark (Salix alba) and intravenous flunixin meglumine on prostaglandin E(2) in healthy dairy calves
title_fullStr Effects of oral white willow bark (Salix alba) and intravenous flunixin meglumine on prostaglandin E(2) in healthy dairy calves
title_full_unstemmed Effects of oral white willow bark (Salix alba) and intravenous flunixin meglumine on prostaglandin E(2) in healthy dairy calves
title_short Effects of oral white willow bark (Salix alba) and intravenous flunixin meglumine on prostaglandin E(2) in healthy dairy calves
title_sort effects of oral white willow bark (salix alba) and intravenous flunixin meglumine on prostaglandin e(2) in healthy dairy calves
topic Health, Behavior, and Well-being
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623693/
https://www.ncbi.nlm.nih.gov/pubmed/36340684
http://dx.doi.org/10.3168/jdsc.2021-0138
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