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Effects of intracerebroventricular anandamide administration on feed intake and milk yield of dairy cows
Among the endocannabinoids, N-arachidonylethanolamide (AEA; anandamide) plays a key role in regulating energy homeostasis and energy intake. Recent studies suggest the existence of a peripheral mechanism by which AEA increases feed intake in the short term and modulates whole-body energy metabolism...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623742/ https://www.ncbi.nlm.nih.gov/pubmed/36339733 http://dx.doi.org/10.3168/jdsc.2021-0185 |
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author | Kuhla, Björn van Ackern, Isabel |
author_facet | Kuhla, Björn van Ackern, Isabel |
author_sort | Kuhla, Björn |
collection | PubMed |
description | Among the endocannabinoids, N-arachidonylethanolamide (AEA; anandamide) plays a key role in regulating energy homeostasis and energy intake. Recent studies suggest the existence of a peripheral mechanism by which AEA increases feed intake in the short term and modulates whole-body energy metabolism in dairy cows. Here, we aimed to test the hypothesis that AEA has a long-lasting central effect in increasing feed intake that leads to an increase in milk yield of dairy cows. In the present pilot study, 3 nonpregnant Holstein dairy cows were equipped with an intracerebroventricular (i.c.v.) catheter. Cows were deprived from feed for 2 h and received either no injection or an i.c.v. injection of either 12 μg of AEA or DMSO (control), followed by measurement of feed intake for 10 h and milk yield. Administration of AEA increased 10-h dry matter intake (DMI) by between 1.13 and 2.06 kg, whereas 22-h DMI was only marginally altered. However, compared with the control treatment, AEA reduced daily milk yield by 0.3 to 1.4 L/d in all 3 cows. The results demonstrate that i.c.v. administration of 12 µg of AEA increased 10-h DMI but decreased daily milk yield by a central mechanism. |
format | Online Article Text |
id | pubmed-9623742 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-96237422022-11-04 Effects of intracerebroventricular anandamide administration on feed intake and milk yield of dairy cows Kuhla, Björn van Ackern, Isabel JDS Commun Physiology Among the endocannabinoids, N-arachidonylethanolamide (AEA; anandamide) plays a key role in regulating energy homeostasis and energy intake. Recent studies suggest the existence of a peripheral mechanism by which AEA increases feed intake in the short term and modulates whole-body energy metabolism in dairy cows. Here, we aimed to test the hypothesis that AEA has a long-lasting central effect in increasing feed intake that leads to an increase in milk yield of dairy cows. In the present pilot study, 3 nonpregnant Holstein dairy cows were equipped with an intracerebroventricular (i.c.v.) catheter. Cows were deprived from feed for 2 h and received either no injection or an i.c.v. injection of either 12 μg of AEA or DMSO (control), followed by measurement of feed intake for 10 h and milk yield. Administration of AEA increased 10-h dry matter intake (DMI) by between 1.13 and 2.06 kg, whereas 22-h DMI was only marginally altered. However, compared with the control treatment, AEA reduced daily milk yield by 0.3 to 1.4 L/d in all 3 cows. The results demonstrate that i.c.v. administration of 12 µg of AEA increased 10-h DMI but decreased daily milk yield by a central mechanism. Elsevier 2022-02-10 /pmc/articles/PMC9623742/ /pubmed/36339733 http://dx.doi.org/10.3168/jdsc.2021-0185 Text en © 2022. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Physiology Kuhla, Björn van Ackern, Isabel Effects of intracerebroventricular anandamide administration on feed intake and milk yield of dairy cows |
title | Effects of intracerebroventricular anandamide administration on feed intake and milk yield of dairy cows |
title_full | Effects of intracerebroventricular anandamide administration on feed intake and milk yield of dairy cows |
title_fullStr | Effects of intracerebroventricular anandamide administration on feed intake and milk yield of dairy cows |
title_full_unstemmed | Effects of intracerebroventricular anandamide administration on feed intake and milk yield of dairy cows |
title_short | Effects of intracerebroventricular anandamide administration on feed intake and milk yield of dairy cows |
title_sort | effects of intracerebroventricular anandamide administration on feed intake and milk yield of dairy cows |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623742/ https://www.ncbi.nlm.nih.gov/pubmed/36339733 http://dx.doi.org/10.3168/jdsc.2021-0185 |
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