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Modulation of brain networks during MR-compatible transcranial direct current stimulation

Transcranial direct current stimulation (tDCS) can influence performance on behavioral tasks and improve symptoms of brain conditions. Yet, it remains unclear precisely how tDCS affects brain function and connectivity. Here, we measured changes in functional connectivity (FC) metrics in blood-oxygen...

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Autores principales: Leaver, Amber M., Gonzalez, Sara, Vasavada, Megha, Kubicki, Antoni, Jog, Mayank, Wang, Danny J.J., Woods, Roger P., Espinoza, Randall, Gollan, Jacqueline, Parrish, Todd, Narr, Katherine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623807/
https://www.ncbi.nlm.nih.gov/pubmed/35017127
http://dx.doi.org/10.1016/j.neuroimage.2022.118874
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author Leaver, Amber M.
Gonzalez, Sara
Vasavada, Megha
Kubicki, Antoni
Jog, Mayank
Wang, Danny J.J.
Woods, Roger P.
Espinoza, Randall
Gollan, Jacqueline
Parrish, Todd
Narr, Katherine L.
author_facet Leaver, Amber M.
Gonzalez, Sara
Vasavada, Megha
Kubicki, Antoni
Jog, Mayank
Wang, Danny J.J.
Woods, Roger P.
Espinoza, Randall
Gollan, Jacqueline
Parrish, Todd
Narr, Katherine L.
author_sort Leaver, Amber M.
collection PubMed
description Transcranial direct current stimulation (tDCS) can influence performance on behavioral tasks and improve symptoms of brain conditions. Yet, it remains unclear precisely how tDCS affects brain function and connectivity. Here, we measured changes in functional connectivity (FC) metrics in blood-oxygenation-level-dependent (BOLD) fMRI data acquired during MR-compatible tDCS in a whole-brain analysis with corrections for false discovery rate. Volunteers (n = 64) received active tDCS, sham tDCS, and rest (no stimulation), using one of three previously established electrode tDCS montages targeting left dorsolateral prefrontal cortex (DLPFC, n = 37), lateral temporoparietal area (LTA, n = 16), or superior temporal cortex (STC, n = 11). In brain networks where simulated E field was highest in each montage, connectivity with remote nodes decreased during active tDCS. During active DLPFC-tDCS, connectivity decreased between a fronto-parietal network and subgenual ACC, while during LTA-tDCS connectivity decreased between an auditory-somatomotor network and frontal operculum. Active DLPFC-tDCS was also associated with increased connectivity within an orbitofrontal network overlapping subgenual ACC. Irrespective of montage, FC metrics increased in sensorimotor and attention regions during both active and sham tDCS, which may reflect the cognitive-perceptual demands of tDCS. Taken together, these results indicate that tDCS may have both intended and unintended effects on ongoing brain activity, stressing the importance of including sham, stimulation-absent, and active comparators in basic science and clinical trials of tDCS.
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spelling pubmed-96238072022-11-01 Modulation of brain networks during MR-compatible transcranial direct current stimulation Leaver, Amber M. Gonzalez, Sara Vasavada, Megha Kubicki, Antoni Jog, Mayank Wang, Danny J.J. Woods, Roger P. Espinoza, Randall Gollan, Jacqueline Parrish, Todd Narr, Katherine L. Neuroimage Article Transcranial direct current stimulation (tDCS) can influence performance on behavioral tasks and improve symptoms of brain conditions. Yet, it remains unclear precisely how tDCS affects brain function and connectivity. Here, we measured changes in functional connectivity (FC) metrics in blood-oxygenation-level-dependent (BOLD) fMRI data acquired during MR-compatible tDCS in a whole-brain analysis with corrections for false discovery rate. Volunteers (n = 64) received active tDCS, sham tDCS, and rest (no stimulation), using one of three previously established electrode tDCS montages targeting left dorsolateral prefrontal cortex (DLPFC, n = 37), lateral temporoparietal area (LTA, n = 16), or superior temporal cortex (STC, n = 11). In brain networks where simulated E field was highest in each montage, connectivity with remote nodes decreased during active tDCS. During active DLPFC-tDCS, connectivity decreased between a fronto-parietal network and subgenual ACC, while during LTA-tDCS connectivity decreased between an auditory-somatomotor network and frontal operculum. Active DLPFC-tDCS was also associated with increased connectivity within an orbitofrontal network overlapping subgenual ACC. Irrespective of montage, FC metrics increased in sensorimotor and attention regions during both active and sham tDCS, which may reflect the cognitive-perceptual demands of tDCS. Taken together, these results indicate that tDCS may have both intended and unintended effects on ongoing brain activity, stressing the importance of including sham, stimulation-absent, and active comparators in basic science and clinical trials of tDCS. 2022-04-15 2022-01-10 /pmc/articles/PMC9623807/ /pubmed/35017127 http://dx.doi.org/10.1016/j.neuroimage.2022.118874 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Article
Leaver, Amber M.
Gonzalez, Sara
Vasavada, Megha
Kubicki, Antoni
Jog, Mayank
Wang, Danny J.J.
Woods, Roger P.
Espinoza, Randall
Gollan, Jacqueline
Parrish, Todd
Narr, Katherine L.
Modulation of brain networks during MR-compatible transcranial direct current stimulation
title Modulation of brain networks during MR-compatible transcranial direct current stimulation
title_full Modulation of brain networks during MR-compatible transcranial direct current stimulation
title_fullStr Modulation of brain networks during MR-compatible transcranial direct current stimulation
title_full_unstemmed Modulation of brain networks during MR-compatible transcranial direct current stimulation
title_short Modulation of brain networks during MR-compatible transcranial direct current stimulation
title_sort modulation of brain networks during mr-compatible transcranial direct current stimulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623807/
https://www.ncbi.nlm.nih.gov/pubmed/35017127
http://dx.doi.org/10.1016/j.neuroimage.2022.118874
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