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Direct comparison of echocardiography speckle tracking and cardiac magnetic resonance feature tracking for quantification of right ventricular strain: a prospective intermodality study in functional mitral regurgitation

BACKGROUND: Functional mitral regurgitation (FMR) is a known risk factor for right ventricular dysfunction (RV(DYS)). RV global longitudinal strain (GLS) is an emerging index of RV function; however, the magnitude of agreement between RV GLS by echocardiography (echo) and cardiac magnetic resonance...

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Autores principales: Johannesen, Justin, Fukuda, Rena, Zhang, David T., Tak, Katherine, Meier, Rachel, Agoglia, Hannah, Horn, Evelyn, Devereux, Richard B., Weinsaft, Jonathan W., Kim, Jiwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623949/
https://www.ncbi.nlm.nih.gov/pubmed/36316750
http://dx.doi.org/10.1186/s44156-022-00011-8
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author Johannesen, Justin
Fukuda, Rena
Zhang, David T.
Tak, Katherine
Meier, Rachel
Agoglia, Hannah
Horn, Evelyn
Devereux, Richard B.
Weinsaft, Jonathan W.
Kim, Jiwon
author_facet Johannesen, Justin
Fukuda, Rena
Zhang, David T.
Tak, Katherine
Meier, Rachel
Agoglia, Hannah
Horn, Evelyn
Devereux, Richard B.
Weinsaft, Jonathan W.
Kim, Jiwon
author_sort Johannesen, Justin
collection PubMed
description BACKGROUND: Functional mitral regurgitation (FMR) is a known risk factor for right ventricular dysfunction (RV(DYS)). RV global longitudinal strain (GLS) is an emerging index of RV function; however, the magnitude of agreement between RV GLS by echocardiography (echo) and cardiac magnetic resonance (CMR) and the relative utility of each modality for both the diagnosis of RV(DYS) and prognostication of all-cause mortality and heart failure hospitalization remain unknown. RESULTS: 32% of patients had RV(DYS) (EF < 50%) on CMR, among whom there was more advanced NYHA class and lower LV and RV ejection fraction (all p < 0.05). RV GLS was impaired in patients with RV(DYS) whether quantified via STE or FT-CMR, with strong correlation between modalities (r = 0.81). Both STE and FT-CMR derived GLS yielded excellent detection of RV(DYS) (AUC 0.94 for both), paralleling similar performance for free wall strain by both modalities (FT-CMR AUC 0.94, STE AUC 0.92) with lower accuracy demonstrated by STE derived septal strain (STE AUC 0.78 and FT-CMR AUC 0.92). RV S’ and TAPSE showed lower diagnostic accuracy (RV S’ AUC 0.77 and TAPSE AUC 0.81). During median follow up of 51 months (IQR 42, 60 months), all-cause mortality or HF hospitalization occurred in 25% (n = 25). Both STE and FT-CMR derived RV GLS stratified risk for adverse prognosis (STE p = 0.007, FT-CMR p = 0.005) whereas conventional RV indices, TAPSE and RV S’, did not (TAPSE p = 0.30, S’ p = 0.69). CONCLUSION: RV GLS is a robust marker of RV(DYS) irrespective of modality which provides incremental diagnostic value and improves risk stratification for event free survival beyond conventional RV indices.
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spelling pubmed-96239492022-11-02 Direct comparison of echocardiography speckle tracking and cardiac magnetic resonance feature tracking for quantification of right ventricular strain: a prospective intermodality study in functional mitral regurgitation Johannesen, Justin Fukuda, Rena Zhang, David T. Tak, Katherine Meier, Rachel Agoglia, Hannah Horn, Evelyn Devereux, Richard B. Weinsaft, Jonathan W. Kim, Jiwon Echo Res Pract Research BACKGROUND: Functional mitral regurgitation (FMR) is a known risk factor for right ventricular dysfunction (RV(DYS)). RV global longitudinal strain (GLS) is an emerging index of RV function; however, the magnitude of agreement between RV GLS by echocardiography (echo) and cardiac magnetic resonance (CMR) and the relative utility of each modality for both the diagnosis of RV(DYS) and prognostication of all-cause mortality and heart failure hospitalization remain unknown. RESULTS: 32% of patients had RV(DYS) (EF < 50%) on CMR, among whom there was more advanced NYHA class and lower LV and RV ejection fraction (all p < 0.05). RV GLS was impaired in patients with RV(DYS) whether quantified via STE or FT-CMR, with strong correlation between modalities (r = 0.81). Both STE and FT-CMR derived GLS yielded excellent detection of RV(DYS) (AUC 0.94 for both), paralleling similar performance for free wall strain by both modalities (FT-CMR AUC 0.94, STE AUC 0.92) with lower accuracy demonstrated by STE derived septal strain (STE AUC 0.78 and FT-CMR AUC 0.92). RV S’ and TAPSE showed lower diagnostic accuracy (RV S’ AUC 0.77 and TAPSE AUC 0.81). During median follow up of 51 months (IQR 42, 60 months), all-cause mortality or HF hospitalization occurred in 25% (n = 25). Both STE and FT-CMR derived RV GLS stratified risk for adverse prognosis (STE p = 0.007, FT-CMR p = 0.005) whereas conventional RV indices, TAPSE and RV S’, did not (TAPSE p = 0.30, S’ p = 0.69). CONCLUSION: RV GLS is a robust marker of RV(DYS) irrespective of modality which provides incremental diagnostic value and improves risk stratification for event free survival beyond conventional RV indices. BioMed Central 2022-11-01 /pmc/articles/PMC9623949/ /pubmed/36316750 http://dx.doi.org/10.1186/s44156-022-00011-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Johannesen, Justin
Fukuda, Rena
Zhang, David T.
Tak, Katherine
Meier, Rachel
Agoglia, Hannah
Horn, Evelyn
Devereux, Richard B.
Weinsaft, Jonathan W.
Kim, Jiwon
Direct comparison of echocardiography speckle tracking and cardiac magnetic resonance feature tracking for quantification of right ventricular strain: a prospective intermodality study in functional mitral regurgitation
title Direct comparison of echocardiography speckle tracking and cardiac magnetic resonance feature tracking for quantification of right ventricular strain: a prospective intermodality study in functional mitral regurgitation
title_full Direct comparison of echocardiography speckle tracking and cardiac magnetic resonance feature tracking for quantification of right ventricular strain: a prospective intermodality study in functional mitral regurgitation
title_fullStr Direct comparison of echocardiography speckle tracking and cardiac magnetic resonance feature tracking for quantification of right ventricular strain: a prospective intermodality study in functional mitral regurgitation
title_full_unstemmed Direct comparison of echocardiography speckle tracking and cardiac magnetic resonance feature tracking for quantification of right ventricular strain: a prospective intermodality study in functional mitral regurgitation
title_short Direct comparison of echocardiography speckle tracking and cardiac magnetic resonance feature tracking for quantification of right ventricular strain: a prospective intermodality study in functional mitral regurgitation
title_sort direct comparison of echocardiography speckle tracking and cardiac magnetic resonance feature tracking for quantification of right ventricular strain: a prospective intermodality study in functional mitral regurgitation
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623949/
https://www.ncbi.nlm.nih.gov/pubmed/36316750
http://dx.doi.org/10.1186/s44156-022-00011-8
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