Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality

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Viruses co-opt host proteins to carry out their lifecycle. Repurposed host proteins may thus become functionally compromised; a situation analogous to a loss-of-function mutation. We term such host proteins as viral-induced hypomorphs. Cells bearing cancer driver loss-of-function mutations have succ...

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Detalles Bibliográficos
Autores principales: Navare, Arti T., Mast, Fred D., Olivier, Jean Paul, Bertomeu, Thierry, Neal, Maxwell L., Carpp, Lindsay N., Kaushansky, Alexis, Coulombe-Huntington, Jasmin, Tyers, Mike, Aitchison, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623979/
https://www.ncbi.nlm.nih.gov/pubmed/36305789
http://dx.doi.org/10.1083/jcb.202011050

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