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Hepatitis B or C viral infection and the risk of cervical cancer

BACKGROUND: The present study aimed to evaluate the effects of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection on the risk of cervical cancer. METHODS: We conducted a case–control study including 838 cervical cancer cases and 838 benign disease controls matched for age, ethnicity, and p...

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Autores principales: Luo, Chuanfang, Yu, Shuhui, Zhang, Jinping, Wu, Xingrao, Dou, Zhongyan, Li, Zheng, Yang, E., Zhang, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624004/
https://www.ncbi.nlm.nih.gov/pubmed/36320009
http://dx.doi.org/10.1186/s13027-022-00466-8
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author Luo, Chuanfang
Yu, Shuhui
Zhang, Jinping
Wu, Xingrao
Dou, Zhongyan
Li, Zheng
Yang, E.
Zhang, Lan
author_facet Luo, Chuanfang
Yu, Shuhui
Zhang, Jinping
Wu, Xingrao
Dou, Zhongyan
Li, Zheng
Yang, E.
Zhang, Lan
author_sort Luo, Chuanfang
collection PubMed
description BACKGROUND: The present study aimed to evaluate the effects of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection on the risk of cervical cancer. METHODS: We conducted a case–control study including 838 cervical cancer cases and 838 benign disease controls matched for age, ethnicity, and place of birth. Venous blood was tested for HBV and HCV serological markers. Multiple odds ratios (OR) and corresponding 95% confidence intervals (CI) for cervical cancer were estimated using logistic regression. HBV antigens were examined using immunohistochemical staining. RESULTS: Anti-HCV was positive in 10 cases (1.2%) and 0 controls (0%). Cases had higher percentage of chronic HBV infection (HBsAg-positive/anti-HBc-positive) and prior HBV infection (HBsAg-negative/anti-HBc-positive) than controls (6.3% vs 4.4%; 11.6% vs 7.3%). Both chronic HBV infection (OR 1.6; 95% CI 1.0–2.4) and prior HBV infection (OR 1.7; 95% CI 1.2–2.4) were associated with cervical cancer in univariate logistic regression analyses. In subgroup analysis among HPV-positive patients, the association between chronic HBV infection and cervical cancer disappeared (OR 1.2; 95% CI 0.4–3.4); while in subgroup among patients younger than 50 years, the association remained significant with adjustment for HPV infection and parity (adjusted OR 2.1; 95% CI 1.0–4.4). HBsAg and HBcAg were detected in 8% and 12% of cervical cancer cases who had seropositive HBsAg, respectively. Compared with the benign controls, individuals with both HBsAg and HPV positive had an increased risk of cervical cancer (adjusted OR 67.1; 95% CI 23.4–192.7). CONCLUSIONS: HBV infection was associated with cervical cancer in patients with age younger than 50 years. Further prospective studies are needed to confirm this relationship. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13027-022-00466-8.
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spelling pubmed-96240042022-11-02 Hepatitis B or C viral infection and the risk of cervical cancer Luo, Chuanfang Yu, Shuhui Zhang, Jinping Wu, Xingrao Dou, Zhongyan Li, Zheng Yang, E. Zhang, Lan Infect Agent Cancer Research BACKGROUND: The present study aimed to evaluate the effects of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection on the risk of cervical cancer. METHODS: We conducted a case–control study including 838 cervical cancer cases and 838 benign disease controls matched for age, ethnicity, and place of birth. Venous blood was tested for HBV and HCV serological markers. Multiple odds ratios (OR) and corresponding 95% confidence intervals (CI) for cervical cancer were estimated using logistic regression. HBV antigens were examined using immunohistochemical staining. RESULTS: Anti-HCV was positive in 10 cases (1.2%) and 0 controls (0%). Cases had higher percentage of chronic HBV infection (HBsAg-positive/anti-HBc-positive) and prior HBV infection (HBsAg-negative/anti-HBc-positive) than controls (6.3% vs 4.4%; 11.6% vs 7.3%). Both chronic HBV infection (OR 1.6; 95% CI 1.0–2.4) and prior HBV infection (OR 1.7; 95% CI 1.2–2.4) were associated with cervical cancer in univariate logistic regression analyses. In subgroup analysis among HPV-positive patients, the association between chronic HBV infection and cervical cancer disappeared (OR 1.2; 95% CI 0.4–3.4); while in subgroup among patients younger than 50 years, the association remained significant with adjustment for HPV infection and parity (adjusted OR 2.1; 95% CI 1.0–4.4). HBsAg and HBcAg were detected in 8% and 12% of cervical cancer cases who had seropositive HBsAg, respectively. Compared with the benign controls, individuals with both HBsAg and HPV positive had an increased risk of cervical cancer (adjusted OR 67.1; 95% CI 23.4–192.7). CONCLUSIONS: HBV infection was associated with cervical cancer in patients with age younger than 50 years. Further prospective studies are needed to confirm this relationship. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13027-022-00466-8. BioMed Central 2022-11-01 /pmc/articles/PMC9624004/ /pubmed/36320009 http://dx.doi.org/10.1186/s13027-022-00466-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Luo, Chuanfang
Yu, Shuhui
Zhang, Jinping
Wu, Xingrao
Dou, Zhongyan
Li, Zheng
Yang, E.
Zhang, Lan
Hepatitis B or C viral infection and the risk of cervical cancer
title Hepatitis B or C viral infection and the risk of cervical cancer
title_full Hepatitis B or C viral infection and the risk of cervical cancer
title_fullStr Hepatitis B or C viral infection and the risk of cervical cancer
title_full_unstemmed Hepatitis B or C viral infection and the risk of cervical cancer
title_short Hepatitis B or C viral infection and the risk of cervical cancer
title_sort hepatitis b or c viral infection and the risk of cervical cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624004/
https://www.ncbi.nlm.nih.gov/pubmed/36320009
http://dx.doi.org/10.1186/s13027-022-00466-8
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