Pilot study on CHCF1 genotype in a pig challenge model for enterotoxigenic Escherichia coli F4ab/ac associated post-weaning diarrhea

Host genotype is important for enterotoxigenic E. coli (ETEC) susceptibility. We conducted two trials to evaluate the effect of CHCF1 genotype on incidence of ETEC diarrhea. In trial 1 (n = 15 pigs), pigs were inoculated with 10(8) CFU or 10(10) CFU doses of an ETEC F4ac strain. In trial 2 (n = 33 p...

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Detalles Bibliográficos
Autores principales: Rydal, Martin Peter, Gambino, Michela, Jørgensen, Claus Bøttcher, Poulsen, Louise Ladefoged, Brøndsted, Lone, Nielsen, Jens Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624054/
https://www.ncbi.nlm.nih.gov/pubmed/36320033
http://dx.doi.org/10.1186/s12917-022-03474-3
Descripción
Sumario:Host genotype is important for enterotoxigenic E. coli (ETEC) susceptibility. We conducted two trials to evaluate the effect of CHCF1 genotype on incidence of ETEC diarrhea. In trial 1 (n = 15 pigs), pigs were inoculated with 10(8) CFU or 10(10) CFU doses of an ETEC F4ac strain. In trial 2 (n = 33 pigs), pigs were inoculated with ETEC F4ab or F4ac. Across trials, all inoculated pigs that developed ETEC diarrhea were CHCF1 heterozygous susceptible (6/6). No inoculated CHCF1 homozygous resistant pigs developed ETEC diarrhea (0/26). Susceptibility towards ETEC F4ac/ab infection might correspond with CHCF1 genotype. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12917-022-03474-3.

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