A multivariate comparison of electroencephalogram and functional magnetic resonance imaging to electrocorticogram using visual object representations in humans

Today, most neurocognitive studies in humans employ the non-invasive neuroimaging techniques functional magnetic resonance imaging (fMRI) and electroencephalogram (EEG). However, how the data provided by fMRI and EEG relate exactly to the underlying neural activity remains incompletely understood. Here, we aimed to understand the relation between EEG and fMRI data at the level of neural population codes using multivariate pattern analysis. In particular, we assessed whether this relation is affected when we change stimuli or introduce identity-preserving variations to them. For this, we recorded EEG and fMRI data separately from 21 healthy participants while participants viewed everyday objects in different viewing conditions, and then related the data to electrocorticogram (ECoG) data recorded for the same stimulus set from epileptic patients. The comparison of EEG and ECoG data showed that object category signals emerge swiftly in the visual system and can be detected by both EEG and ECoG at similar temporal delays after stimulus onset. The correlation between EEG and ECoG was reduced when object representations tolerant to changes in scale and orientation were considered. The comparison of fMRI and ECoG overall revealed a tighter relationship in occipital than in temporal regions, related to differences in fMRI signal-to-noise ratio. Together, our results reveal a complex relationship between fMRI, EEG, and ECoG signals at the level of population codes that critically depends on the time point after stimulus onset, the region investigated, and the visual contents used.