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Livedoid skin reaction to 2nd dose of mRNA Covid-19 vaccine

Skin often represents a target organ for adverse drug reactions and this also applies to the mRNA vaccines against Sars-CoV-2. Here we present a case of extensive livedoid reaction after 2nd dose of BNT162b-2 vaccine with massive blood skin extravasation and no systemic symptoms apart from anemizati...

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Autores principales: Girolami, Ilaria, Eisendle, Klaus, Kluge, Reinhard Walther, Hanspeter, Esther, Eccher, Albino, Vizziello, Leonardo, Zampieri, Pierfrancesco, Mazzoleni, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pacini Editore srl 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624132/
https://www.ncbi.nlm.nih.gov/pubmed/36136900
http://dx.doi.org/10.32074/1591-951X-746
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author Girolami, Ilaria
Eisendle, Klaus
Kluge, Reinhard Walther
Hanspeter, Esther
Eccher, Albino
Vizziello, Leonardo
Zampieri, Pierfrancesco
Mazzoleni, Guido
author_facet Girolami, Ilaria
Eisendle, Klaus
Kluge, Reinhard Walther
Hanspeter, Esther
Eccher, Albino
Vizziello, Leonardo
Zampieri, Pierfrancesco
Mazzoleni, Guido
author_sort Girolami, Ilaria
collection PubMed
description Skin often represents a target organ for adverse drug reactions and this also applies to the mRNA vaccines against Sars-CoV-2. Here we present a case of extensive livedoid reaction after 2nd dose of BNT162b-2 vaccine with massive blood skin extravasation and no systemic symptoms apart from anemization. The 30-year-old woman developed progressively enlarging livedoid lesions on limbs and abdomen. Histology showed a near-normal epidermis and a very mild interstitial mixed inflammatory infiltrate with extensive blood extravasation in mid- and deep dermis. Diagnosis was adverse reaction to vaccine with skin capillary hyperpermeability and anaemization with lower than diagnostic features of cutaneous small vessel vasculitis. To date, no cases of a livedoid skin reaction associated to Covid-19 vaccine have been reported, and this case illustrates that massive livedoid reaction can be another kind of skin reaction to mRNA Covid-19 vaccine.
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spelling pubmed-96241322022-11-07 Livedoid skin reaction to 2nd dose of mRNA Covid-19 vaccine Girolami, Ilaria Eisendle, Klaus Kluge, Reinhard Walther Hanspeter, Esther Eccher, Albino Vizziello, Leonardo Zampieri, Pierfrancesco Mazzoleni, Guido Pathologica Case Report Skin often represents a target organ for adverse drug reactions and this also applies to the mRNA vaccines against Sars-CoV-2. Here we present a case of extensive livedoid reaction after 2nd dose of BNT162b-2 vaccine with massive blood skin extravasation and no systemic symptoms apart from anemization. The 30-year-old woman developed progressively enlarging livedoid lesions on limbs and abdomen. Histology showed a near-normal epidermis and a very mild interstitial mixed inflammatory infiltrate with extensive blood extravasation in mid- and deep dermis. Diagnosis was adverse reaction to vaccine with skin capillary hyperpermeability and anaemization with lower than diagnostic features of cutaneous small vessel vasculitis. To date, no cases of a livedoid skin reaction associated to Covid-19 vaccine have been reported, and this case illustrates that massive livedoid reaction can be another kind of skin reaction to mRNA Covid-19 vaccine. Pacini Editore srl 2022-08-01 /pmc/articles/PMC9624132/ /pubmed/36136900 http://dx.doi.org/10.32074/1591-951X-746 Text en © 2022 Copyright by Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access journal distributed in accordance with the CC-BY-NC-ND (Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International) license: the work can be used by mentioning the author and the license, but only for non-commercial purposes and only in the original version. For further information: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en
spellingShingle Case Report
Girolami, Ilaria
Eisendle, Klaus
Kluge, Reinhard Walther
Hanspeter, Esther
Eccher, Albino
Vizziello, Leonardo
Zampieri, Pierfrancesco
Mazzoleni, Guido
Livedoid skin reaction to 2nd dose of mRNA Covid-19 vaccine
title Livedoid skin reaction to 2nd dose of mRNA Covid-19 vaccine
title_full Livedoid skin reaction to 2nd dose of mRNA Covid-19 vaccine
title_fullStr Livedoid skin reaction to 2nd dose of mRNA Covid-19 vaccine
title_full_unstemmed Livedoid skin reaction to 2nd dose of mRNA Covid-19 vaccine
title_short Livedoid skin reaction to 2nd dose of mRNA Covid-19 vaccine
title_sort livedoid skin reaction to 2nd dose of mrna covid-19 vaccine
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624132/
https://www.ncbi.nlm.nih.gov/pubmed/36136900
http://dx.doi.org/10.32074/1591-951X-746
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