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Danicopan, an Oral Complement Factor D Inhibitor, Exhibits High and Sustained Exposure in Ocular Tissues in Preclinical Studies

PURPOSE: Complement alternative pathway (AP) dysregulation has been implicated in geographic atrophy, an advanced form of age-related macular degeneration. Danicopan is an investigational, first-in-class inhibitor of factor D, an essential AP activation enzyme. We assessed danicopan distribution to...

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Detalles Bibliográficos
Autores principales:	Boyer, David D., Ko, Ya-Ping, Podos, Steven D., Cartwright, Mark E., Gao, Xiang, Wiles, Jason A., Huang, Mingjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2022
Materias:	Retina
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624268/ https://www.ncbi.nlm.nih.gov/pubmed/36301553 http://dx.doi.org/10.1167/tvst.11.10.37

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