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Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study

Complex breast cancer (BC) treatment can cause various neurological and psychiatric complications, such as postmastectomy pain syndrome, vestibulocerebellar ataxia, and depression, which can lead to microstructural damage of the white matter tracts of the brain. The purpose of the study is to assess...

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Autores principales: Bukkieva, Tatyana, Pospelova, Maria, Efimtsev, Aleksandr, Fionik, Olga, Alekseeva, Tatyana, Samochernykh, Konstantin, Gorbunova, Elena, Krasnikova, Varvara, Makhanova, Albina, Nikolaeva, Aleksandra, Tonyan, Samvel, Lepekhina, Anna, Levchuk, Anatoliy, Trufanov, Gennadiy, Akshulakov, Serik, Shevtsov, Maxim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624319/
https://www.ncbi.nlm.nih.gov/pubmed/36278563
http://dx.doi.org/10.3390/pathophysiology29040046
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author Bukkieva, Tatyana
Pospelova, Maria
Efimtsev, Aleksandr
Fionik, Olga
Alekseeva, Tatyana
Samochernykh, Konstantin
Gorbunova, Elena
Krasnikova, Varvara
Makhanova, Albina
Nikolaeva, Aleksandra
Tonyan, Samvel
Lepekhina, Anna
Levchuk, Anatoliy
Trufanov, Gennadiy
Akshulakov, Serik
Shevtsov, Maxim
author_facet Bukkieva, Tatyana
Pospelova, Maria
Efimtsev, Aleksandr
Fionik, Olga
Alekseeva, Tatyana
Samochernykh, Konstantin
Gorbunova, Elena
Krasnikova, Varvara
Makhanova, Albina
Nikolaeva, Aleksandra
Tonyan, Samvel
Lepekhina, Anna
Levchuk, Anatoliy
Trufanov, Gennadiy
Akshulakov, Serik
Shevtsov, Maxim
author_sort Bukkieva, Tatyana
collection PubMed
description Complex breast cancer (BC) treatment can cause various neurological and psychiatric complications, such as postmastectomy pain syndrome, vestibulocerebellar ataxia, and depression, which can lead to microstructural damage of the white matter tracts of the brain. The purpose of the study is to assess microstructural changes in the white matter tracts of the brain in BC survivors using diffusion tensor imaging (DTI). Single DTI scans were performed on patients (n = 84) after complex BC treatment (i.e., surgery, chemotherapy and/or radiation therapy) and on the control group (n = 40). According to the results, a decrease in the quantitative anisotropy (FDR ≤ 0.05) was revealed in the bilateral corticospinal tracts, cerebellar tracts, corpus callosum, fornix, left superior corticostriatal and left corticopontine parietal in patients after BC treatment in comparison to the control group. A decrease in the quantitative anisotropy (FDR ≤ 0.05) was also revealed in the corpus callosum and right cerebellar tracts in patients after BC treatment with the presence of postmastectomy pain syndrome and vestibulocerebellar ataxia. The use of DTI in patients after BC treatment reveals microstructural properties of the white matter tracts in the brain. The results will allow for the improvement of treatment and rehabilitation approaches in patients receiving treatment for breast cancer.
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spelling pubmed-96243192022-11-02 Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study Bukkieva, Tatyana Pospelova, Maria Efimtsev, Aleksandr Fionik, Olga Alekseeva, Tatyana Samochernykh, Konstantin Gorbunova, Elena Krasnikova, Varvara Makhanova, Albina Nikolaeva, Aleksandra Tonyan, Samvel Lepekhina, Anna Levchuk, Anatoliy Trufanov, Gennadiy Akshulakov, Serik Shevtsov, Maxim Pathophysiology Article Complex breast cancer (BC) treatment can cause various neurological and psychiatric complications, such as postmastectomy pain syndrome, vestibulocerebellar ataxia, and depression, which can lead to microstructural damage of the white matter tracts of the brain. The purpose of the study is to assess microstructural changes in the white matter tracts of the brain in BC survivors using diffusion tensor imaging (DTI). Single DTI scans were performed on patients (n = 84) after complex BC treatment (i.e., surgery, chemotherapy and/or radiation therapy) and on the control group (n = 40). According to the results, a decrease in the quantitative anisotropy (FDR ≤ 0.05) was revealed in the bilateral corticospinal tracts, cerebellar tracts, corpus callosum, fornix, left superior corticostriatal and left corticopontine parietal in patients after BC treatment in comparison to the control group. A decrease in the quantitative anisotropy (FDR ≤ 0.05) was also revealed in the corpus callosum and right cerebellar tracts in patients after BC treatment with the presence of postmastectomy pain syndrome and vestibulocerebellar ataxia. The use of DTI in patients after BC treatment reveals microstructural properties of the white matter tracts in the brain. The results will allow for the improvement of treatment and rehabilitation approaches in patients receiving treatment for breast cancer. MDPI 2022-10-17 /pmc/articles/PMC9624319/ /pubmed/36278563 http://dx.doi.org/10.3390/pathophysiology29040046 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bukkieva, Tatyana
Pospelova, Maria
Efimtsev, Aleksandr
Fionik, Olga
Alekseeva, Tatyana
Samochernykh, Konstantin
Gorbunova, Elena
Krasnikova, Varvara
Makhanova, Albina
Nikolaeva, Aleksandra
Tonyan, Samvel
Lepekhina, Anna
Levchuk, Anatoliy
Trufanov, Gennadiy
Akshulakov, Serik
Shevtsov, Maxim
Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study
title Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study
title_full Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study
title_fullStr Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study
title_full_unstemmed Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study
title_short Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study
title_sort microstructural properties of brain white matter tracts in breast cancer survivors: a diffusion tensor imaging study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624319/
https://www.ncbi.nlm.nih.gov/pubmed/36278563
http://dx.doi.org/10.3390/pathophysiology29040046
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