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Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study
Complex breast cancer (BC) treatment can cause various neurological and psychiatric complications, such as postmastectomy pain syndrome, vestibulocerebellar ataxia, and depression, which can lead to microstructural damage of the white matter tracts of the brain. The purpose of the study is to assess...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624319/ https://www.ncbi.nlm.nih.gov/pubmed/36278563 http://dx.doi.org/10.3390/pathophysiology29040046 |
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author | Bukkieva, Tatyana Pospelova, Maria Efimtsev, Aleksandr Fionik, Olga Alekseeva, Tatyana Samochernykh, Konstantin Gorbunova, Elena Krasnikova, Varvara Makhanova, Albina Nikolaeva, Aleksandra Tonyan, Samvel Lepekhina, Anna Levchuk, Anatoliy Trufanov, Gennadiy Akshulakov, Serik Shevtsov, Maxim |
author_facet | Bukkieva, Tatyana Pospelova, Maria Efimtsev, Aleksandr Fionik, Olga Alekseeva, Tatyana Samochernykh, Konstantin Gorbunova, Elena Krasnikova, Varvara Makhanova, Albina Nikolaeva, Aleksandra Tonyan, Samvel Lepekhina, Anna Levchuk, Anatoliy Trufanov, Gennadiy Akshulakov, Serik Shevtsov, Maxim |
author_sort | Bukkieva, Tatyana |
collection | PubMed |
description | Complex breast cancer (BC) treatment can cause various neurological and psychiatric complications, such as postmastectomy pain syndrome, vestibulocerebellar ataxia, and depression, which can lead to microstructural damage of the white matter tracts of the brain. The purpose of the study is to assess microstructural changes in the white matter tracts of the brain in BC survivors using diffusion tensor imaging (DTI). Single DTI scans were performed on patients (n = 84) after complex BC treatment (i.e., surgery, chemotherapy and/or radiation therapy) and on the control group (n = 40). According to the results, a decrease in the quantitative anisotropy (FDR ≤ 0.05) was revealed in the bilateral corticospinal tracts, cerebellar tracts, corpus callosum, fornix, left superior corticostriatal and left corticopontine parietal in patients after BC treatment in comparison to the control group. A decrease in the quantitative anisotropy (FDR ≤ 0.05) was also revealed in the corpus callosum and right cerebellar tracts in patients after BC treatment with the presence of postmastectomy pain syndrome and vestibulocerebellar ataxia. The use of DTI in patients after BC treatment reveals microstructural properties of the white matter tracts in the brain. The results will allow for the improvement of treatment and rehabilitation approaches in patients receiving treatment for breast cancer. |
format | Online Article Text |
id | pubmed-9624319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96243192022-11-02 Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study Bukkieva, Tatyana Pospelova, Maria Efimtsev, Aleksandr Fionik, Olga Alekseeva, Tatyana Samochernykh, Konstantin Gorbunova, Elena Krasnikova, Varvara Makhanova, Albina Nikolaeva, Aleksandra Tonyan, Samvel Lepekhina, Anna Levchuk, Anatoliy Trufanov, Gennadiy Akshulakov, Serik Shevtsov, Maxim Pathophysiology Article Complex breast cancer (BC) treatment can cause various neurological and psychiatric complications, such as postmastectomy pain syndrome, vestibulocerebellar ataxia, and depression, which can lead to microstructural damage of the white matter tracts of the brain. The purpose of the study is to assess microstructural changes in the white matter tracts of the brain in BC survivors using diffusion tensor imaging (DTI). Single DTI scans were performed on patients (n = 84) after complex BC treatment (i.e., surgery, chemotherapy and/or radiation therapy) and on the control group (n = 40). According to the results, a decrease in the quantitative anisotropy (FDR ≤ 0.05) was revealed in the bilateral corticospinal tracts, cerebellar tracts, corpus callosum, fornix, left superior corticostriatal and left corticopontine parietal in patients after BC treatment in comparison to the control group. A decrease in the quantitative anisotropy (FDR ≤ 0.05) was also revealed in the corpus callosum and right cerebellar tracts in patients after BC treatment with the presence of postmastectomy pain syndrome and vestibulocerebellar ataxia. The use of DTI in patients after BC treatment reveals microstructural properties of the white matter tracts in the brain. The results will allow for the improvement of treatment and rehabilitation approaches in patients receiving treatment for breast cancer. MDPI 2022-10-17 /pmc/articles/PMC9624319/ /pubmed/36278563 http://dx.doi.org/10.3390/pathophysiology29040046 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bukkieva, Tatyana Pospelova, Maria Efimtsev, Aleksandr Fionik, Olga Alekseeva, Tatyana Samochernykh, Konstantin Gorbunova, Elena Krasnikova, Varvara Makhanova, Albina Nikolaeva, Aleksandra Tonyan, Samvel Lepekhina, Anna Levchuk, Anatoliy Trufanov, Gennadiy Akshulakov, Serik Shevtsov, Maxim Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study |
title | Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study |
title_full | Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study |
title_fullStr | Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study |
title_full_unstemmed | Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study |
title_short | Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study |
title_sort | microstructural properties of brain white matter tracts in breast cancer survivors: a diffusion tensor imaging study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624319/ https://www.ncbi.nlm.nih.gov/pubmed/36278563 http://dx.doi.org/10.3390/pathophysiology29040046 |
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