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Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta

HIGHLIGHTS: Radiation treatment of tubular prostheses based on a mixture of copolymers of VDF/HFP achieved mechanical behavior of the aorta. Optimum mechanical properties of tubular prostheses were achieved at a dose of 0.3 MGy. The mechanical properties of the fabricated vessel created favorable co...

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Autores principales: Gorodkov, Alexander Yu., Tsygankov, Yuriy M., Shepelev, Alexey D., Krasheninnikov, Sergey V., Zhorzholiani, Shota T., Agafonov, Andrey V., Mamagulashvili, Vissarion G., Savinov, Dmitriy V., Tenchurin, Timur Kh., Chvalun, Sergey N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624334/
https://www.ncbi.nlm.nih.gov/pubmed/36278661
http://dx.doi.org/10.3390/jfb13040192
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author Gorodkov, Alexander Yu.
Tsygankov, Yuriy M.
Shepelev, Alexey D.
Krasheninnikov, Sergey V.
Zhorzholiani, Shota T.
Agafonov, Andrey V.
Mamagulashvili, Vissarion G.
Savinov, Dmitriy V.
Tenchurin, Timur Kh.
Chvalun, Sergey N.
author_facet Gorodkov, Alexander Yu.
Tsygankov, Yuriy M.
Shepelev, Alexey D.
Krasheninnikov, Sergey V.
Zhorzholiani, Shota T.
Agafonov, Andrey V.
Mamagulashvili, Vissarion G.
Savinov, Dmitriy V.
Tenchurin, Timur Kh.
Chvalun, Sergey N.
author_sort Gorodkov, Alexander Yu.
collection PubMed
description HIGHLIGHTS: Radiation treatment of tubular prostheses based on a mixture of copolymers of VDF/HFP achieved mechanical behavior of the aorta. Optimum mechanical properties of tubular prostheses were achieved at a dose of 0.3 MGy. The mechanical properties of the fabricated vessel created favorable conditions for restoration of the neovessel. ABSTRACT: A significant drawback of the rigid synthetic vascular prostheses used in the clinic is the mechanical mismatch between the implant and the prosthetic vessel. When placing prostheses with radial elasticity, in which this deficiency is compensated, the integration of the graft occurs more favorably, so that signs of cell differentiation appear in the prosthesis capsule, which contributes to the restoration of vascular tone and the possibility of vasomotor reactions. Aortic prostheses fabricated by electrospinning from a blend of copolymers of vinylidene fluoride with hexafluoropropylene (VDF/HFP) had a biomechanical behavior comparable to the native aorta. In the present study, to ensure mechanical stability in the conditions of a living organism, the fabricated blood vessel prostheses (BVP) were cross-linked with γ-radiation. An optimal absorbed dose of 0.3 MGy was determined. The obtained samples were implanted into the infrarenal aorta of laboratory animals—Landrace pigs. Histological studies have shown that the connective capsule that forms around the prosthesis has signs of high tissue organization. This is evidenced by the cells of the fibroblast series located in layers oriented along and across the prosthesis, similar to the orientation of cells in a biological arterial vessel.
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spelling pubmed-96243342022-11-02 Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta Gorodkov, Alexander Yu. Tsygankov, Yuriy M. Shepelev, Alexey D. Krasheninnikov, Sergey V. Zhorzholiani, Shota T. Agafonov, Andrey V. Mamagulashvili, Vissarion G. Savinov, Dmitriy V. Tenchurin, Timur Kh. Chvalun, Sergey N. J Funct Biomater Article HIGHLIGHTS: Radiation treatment of tubular prostheses based on a mixture of copolymers of VDF/HFP achieved mechanical behavior of the aorta. Optimum mechanical properties of tubular prostheses were achieved at a dose of 0.3 MGy. The mechanical properties of the fabricated vessel created favorable conditions for restoration of the neovessel. ABSTRACT: A significant drawback of the rigid synthetic vascular prostheses used in the clinic is the mechanical mismatch between the implant and the prosthetic vessel. When placing prostheses with radial elasticity, in which this deficiency is compensated, the integration of the graft occurs more favorably, so that signs of cell differentiation appear in the prosthesis capsule, which contributes to the restoration of vascular tone and the possibility of vasomotor reactions. Aortic prostheses fabricated by electrospinning from a blend of copolymers of vinylidene fluoride with hexafluoropropylene (VDF/HFP) had a biomechanical behavior comparable to the native aorta. In the present study, to ensure mechanical stability in the conditions of a living organism, the fabricated blood vessel prostheses (BVP) were cross-linked with γ-radiation. An optimal absorbed dose of 0.3 MGy was determined. The obtained samples were implanted into the infrarenal aorta of laboratory animals—Landrace pigs. Histological studies have shown that the connective capsule that forms around the prosthesis has signs of high tissue organization. This is evidenced by the cells of the fibroblast series located in layers oriented along and across the prosthesis, similar to the orientation of cells in a biological arterial vessel. MDPI 2022-10-17 /pmc/articles/PMC9624334/ /pubmed/36278661 http://dx.doi.org/10.3390/jfb13040192 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gorodkov, Alexander Yu.
Tsygankov, Yuriy M.
Shepelev, Alexey D.
Krasheninnikov, Sergey V.
Zhorzholiani, Shota T.
Agafonov, Andrey V.
Mamagulashvili, Vissarion G.
Savinov, Dmitriy V.
Tenchurin, Timur Kh.
Chvalun, Sergey N.
Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta
title Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta
title_full Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta
title_fullStr Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta
title_full_unstemmed Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta
title_short Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta
title_sort influence of γ-radiation on mechanical stability to cyclic loads tubular elastic matrix of the aorta
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624334/
https://www.ncbi.nlm.nih.gov/pubmed/36278661
http://dx.doi.org/10.3390/jfb13040192
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