The PD-1/PD-L1 pathway is induced during Borrelia burgdorferi infection and inhibits T cell joint infiltration without compromising bacterial clearance

The Lyme disease bacterial pathogen, Borrelia burgdorferi, establishes a long-term infection inside its mammalian hosts. Despite the continued presence of the bacteria in animal models of disease, inflammation is transitory and resolves spontaneously. T cells with limited effector functions and the...

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Detalles Bibliográficos
Autores principales: Helble, Jennifer D., McCarthy, Julie E., Sawden, Machlan, Starnbach, Michael N., Hu, Linden T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624412/
https://www.ncbi.nlm.nih.gov/pubmed/36265003
http://dx.doi.org/10.1371/journal.ppat.1010903

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