LBODP044 Effects Of Dietary Supplementation On Progression To Type 2 Diabetes Single Center Randomized Double-blind Placebo-controlled Trial An Interim Analysis At 24 Weeks

OBJECTIVES: To examine the effect of dietary supplements on diabetic risk, blood glucose level and lipid profiles. METHODS: A randomized, double-blinded, placebo-controlled study was conducted at Rajavithi Hospital. Participants with prediabetes were randomly allocated to three arms of dietary supplements: placebo (PL) or curcumin plus fish oil and vitamin D (CFD), or curcumin plus fish oil (CF) for 24 weeks. Primary outcomes of the trial were progression to overt diabetes and glycemic indices (fasting plasma glucose, 75-g OGTT 2-h plasma glucose or HbA1C). Secondary outcomes were body weight change, BMI and lipid profiles. RESULTS: A total of forty-seven participants (PL, n = 16; CFD, n = 15; CF, n = 16) were included in the study. At 24 weeks, the intervention groups significantly lowered the progression of type 2 diabetes among prediabetes individuals, the interventions groups -0.77 ± 1.17, and 0.19 ± 1.28, the placebo group 0.64 ± 1.82, P value = 0. 046 (P<0. 05). However, the results failed to demonstrate the effect of dietary supplements on weight, BMI and blood chemistries. CONCLUSION: The combined dietary supplements which contained curcumin-fish oil-vitamin D, lowered the risk of prediabetes progression to overt diabetes at six months follow up and well-tolerated among the participants. Keywords: dietary supplements, curcumin, fish oil, vitamin d, prediabetes Presentation: No date and time listed