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PSUN136 CCN5/WISP2 gene deficiency improves insulin sensitivity and glucose tolerance in diet-induced obesity, especially in male mice

 : CCN5/WISP2 is a matricellular protein, the expression of which is under the regulation of Wnt signaling and IGF-1. Our initial characterization supports the notion that CCN5 promotes the proliferation and survival of pancreatic β-cells leading to metabolic benefits [1]. Recently, the effects of C...

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Detalles Bibliográficos
Autores principales: Xega, Viktoria, Zakikhani, Mahvash, Lopez, Noah, Shahraki, Marzieh Eskandari, Lyons, Karen M, Liu, Jun-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624652/
http://dx.doi.org/10.1210/jendso/bvac150.749