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PSUN20 The ACSPIRE Trial: 11beta-Hydroxysteroid Dehydrogenase Type 1 (HSD-1) Inhibition for Autonomous Cortisol Secretion and Adrenal Cushing's Syndrome

BACKGROUND: HSD-1, an intracellular enzyme, converts cortisone to cortisol in tissues where cortisol excess is associated with morbidity including liver, adipose, bone, brain, muscle, skin, and eye. SPI-62 is a potent and specific HSD-1 inhibitor in development for treatment of autonomous cortisol s...

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Detalles Bibliográficos
Autores principales:	Czerwiec, Frank S, Drajesk, Jeffrey, Hooper, Sarah, Hunsicker, Kimberley, Jacks, Robert, MacPherson, Jamie, Marmon, Tonya, Katz, David A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Adrenal
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624896/ http://dx.doi.org/10.1210/jendso/bvac150.254

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