ODP248 The Effects of Insulin-like Growth Factor-binding Protein-3 on Metabolism During Short Term Fasting in Mice in Vivo

IGFBP-3 is the main abundant circulating IGFBP and plays an important role in the metabolic effect of IGF-1. We investigated the effects of IGFBP-3 on metabolism in short-term fasting and found that when IGFBP-3 was added to mice, serum triglyceride concentration were significantly enhanced. Fasting...

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Detalles Bibliográficos
Autores principales: Choi, Iee H, Kim, Minsun, Kim, Sun-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Diabetes & Glucose Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624956/
http://dx.doi.org/10.1210/jendso/bvac150.696
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author Choi, Iee H
Kim, Minsun
Kim, Sun-Young
author_facet Choi, Iee H
Kim, Minsun
Kim, Sun-Young
author_sort Choi, Iee H
collection PubMed
description IGFBP-3 is the main abundant circulating IGFBP and plays an important role in the metabolic effect of IGF-1. We investigated the effects of IGFBP-3 on metabolism in short-term fasting and found that when IGFBP-3 was added to mice, serum triglyceride concentration were significantly enhanced. Fasting also significantly enhanced triglyceride concentration in liver and serum to the same degree as IGFBP-3. IGFBP-3 transfection suppressed the expression of ketogenesis and beta oxidation genes in liver after 24 h fasting. Also, they were shown significantly increase oflipolysis related protein expression in peripheral adipocyte and decrease the adipocyte size. Additionally, fat accumulation was more increased in the liver transfected with IGFBP-3 after fasting than controls. These in vivo findings demonstrate that IGFBP-3 has potent lipid metabolism and fasting-antagonizing capability and suggest a role for IGFBP-3 in the pathogenesis and homeostasis control of metabolism. Presentation: No date and time listed
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spelling pubmed-96249562022-11-14 ODP248 The Effects of Insulin-like Growth Factor-binding Protein-3 on Metabolism During Short Term Fasting in Mice in Vivo Choi, Iee H Kim, Minsun Kim, Sun-Young J Endocr Soc Diabetes & Glucose Metabolism IGFBP-3 is the main abundant circulating IGFBP and plays an important role in the metabolic effect of IGF-1. We investigated the effects of IGFBP-3 on metabolism in short-term fasting and found that when IGFBP-3 was added to mice, serum triglyceride concentration were significantly enhanced. Fasting also significantly enhanced triglyceride concentration in liver and serum to the same degree as IGFBP-3. IGFBP-3 transfection suppressed the expression of ketogenesis and beta oxidation genes in liver after 24 h fasting. Also, they were shown significantly increase oflipolysis related protein expression in peripheral adipocyte and decrease the adipocyte size. Additionally, fat accumulation was more increased in the liver transfected with IGFBP-3 after fasting than controls. These in vivo findings demonstrate that IGFBP-3 has potent lipid metabolism and fasting-antagonizing capability and suggest a role for IGFBP-3 in the pathogenesis and homeostasis control of metabolism. Presentation: No date and time listed Oxford University Press 2022-11-01 /pmc/articles/PMC9624956/ http://dx.doi.org/10.1210/jendso/bvac150.696 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Diabetes & Glucose Metabolism
Choi, Iee H
Kim, Minsun
Kim, Sun-Young
ODP248 The Effects of Insulin-like Growth Factor-binding Protein-3 on Metabolism During Short Term Fasting in Mice in Vivo
title ODP248 The Effects of Insulin-like Growth Factor-binding Protein-3 on Metabolism During Short Term Fasting in Mice in Vivo
title_full ODP248 The Effects of Insulin-like Growth Factor-binding Protein-3 on Metabolism During Short Term Fasting in Mice in Vivo
title_fullStr ODP248 The Effects of Insulin-like Growth Factor-binding Protein-3 on Metabolism During Short Term Fasting in Mice in Vivo
title_full_unstemmed ODP248 The Effects of Insulin-like Growth Factor-binding Protein-3 on Metabolism During Short Term Fasting in Mice in Vivo
title_short ODP248 The Effects of Insulin-like Growth Factor-binding Protein-3 on Metabolism During Short Term Fasting in Mice in Vivo
title_sort odp248 the effects of insulin-like growth factor-binding protein-3 on metabolism during short term fasting in mice in vivo
topic Diabetes & Glucose Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624956/
http://dx.doi.org/10.1210/jendso/bvac150.696
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AT kimsunyoung odp248theeffectsofinsulinlikegrowthfactorbindingprotein3onmetabolismduringshorttermfastinginmiceinvivo

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