ODP348 Regional disparities in functional impairment due to arthropathy in patients with acromegaly.

OBJECTIVE: While arthropathy is common in acromegaly (ACRO), its impact on the physical function of patients is not well understood. We sought to compare physical function between patients with a history of ACRO or with a nonfunctioning pituitary adenomas (NFA) who had previously undergone pituitary surgery. METHODS: Sex- and age-matched participants (n=34 for both groups) were recruited from the Halifax Neuropituitary Program. All ACRO patients were in remission with or without medical therapy. All patients completed validated questionnaires related to musculoskeletal disability and symptoms of the upper extremity (QuickDASH), functional impact of arthropathy in the weight-bearing joints (hips: HOOS-JR, knees: KOOS-JR, ankles: Quick-FAAM), and balance (ABC-6). We also assessed the number of falls in the past 12 months. HOOS-JR and KOOS-JR scores were compared using paired t-tests, whereas the Wilcoxon signed-rank test was used to compare DASH, DASH-Work, DASH-Instrument, Quick-FAAM, and ABC-6 scores between the two groups. RESULTS: ACRO compared with NFA patients, respectively, had higher upper-limb musculoskeletal disability and symptoms scores [17. 04 (0-70.45) vs. 4.55 (0-50. 00); p=0. 009]. However, there were no significant differences between the DASH-Work score or DASH-Instrument score between the two groups (p=0.317 and 0.18, respectively). ACRO patients had poorer functional scores for the hip compared with NFA (73.43±22.41 vs 86.45±15.43, p=0. 014) and knee (72.69±22.15 vs. 83.30±17.67, p=0. 056). However, there were no differences in ankle scores (p=0. 097). The number of falls within the last 12 months did not differ between the two groups (p=0.424), but there was a trend towards lower levels of self-confidence to maintain balance in ACRO patients compared with NFA patients (75% (8.33-100% vs90% (28.33-100%, p=0. 051). CONCLUSION: ACRO patients showed significantly lower functionality of upper extremities and hips and a trend to greater functional impairment in the knee joints. Even though the number of falls was not different between the two groups, we did note a trend towards reduced levels of self-confidence to maintain balance in ACRO patients. Presentation: No date and time listed