ODP353 Sustained Suppression of IGF1 with AZP-3813, a Bicyclic 16-Amino Acid Peptide Antagonist of the Human Growth Hormone Receptor and a Potential New Treatment for Acromegaly

Medical treatment of acromegaly is based on either suppressing pituitary GH secretion or inhibiting GH action by preventing interaction with its receptor in order to suppress the elevated levels of IGF1. AZP-3813 is a 16-amino acid, bicyclic peptide antagonist of the GH receptor (GHR) with a KD of 1...

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Detalles Bibliográficos
Autores principales: Culler, Michael, Milano, Stephane, Kurasaki, Haruaki, Tomiyama, Tatsuya, Reid, Patrick, van der Lely, Aart Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Neuroendocrinology and Pituitary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9625173/
http://dx.doi.org/10.1210/jendso/bvac150.1062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9625173/
http://dx.doi.org/10.1210/jendso/bvac150.1062

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