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ODP602 A Rare Case of Nonfunctional Metastatic Pancreatic Neuroendocrine Tumor Transformation into an Insulin-secreting Tumor: A Management Dilemma

Pancreatic neuroendocrine tumors (PNETs) although rare, have recently increased in incidence . Clinically they can be classified as functional or nonfunctional depending on presence or absence of active hormone symptomatology and this has a bearing on prognosis and management . Rarely nonfunctioning...

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Detalles Bibliográficos
Autores principales: Azmath, Misbath, Faisal, Sobia, Kantorovich, Vitaly, Guruli, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9625423/
http://dx.doi.org/10.1210/jendso/bvac150.1081
Descripción
Sumario:Pancreatic neuroendocrine tumors (PNETs) although rare, have recently increased in incidence . Clinically they can be classified as functional or nonfunctional depending on presence or absence of active hormone symptomatology and this has a bearing on prognosis and management . Rarely nonfunctioning tumors can undergo biological transformation into a hormone-secreting tumor. We present a rare clinical scenario of a young male with widely metastatic nonfunctional PNET who later presented with profound hypoglycemia with concerns for transformation into an insulin secreting tumor. Presentation: No date and time listed