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OR18-4 Crinecerfont (NBI-74788), a Novel CRF1 Receptor Antagonist, Lowers Adrenal Androgens and Precursors in Adolescents with Classic Congenital Adrenal Hyperplasia

INTRODUCTION: Classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) is a rare autosomal recessive disease characterized by deficiency of cortisol and oftentimes aldosterone, with elevated adrenocorticotropic hormone (ACTH) and steroid precursors that are then shunted...

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Autores principales:	Auchus, Richard, Chan, Jean, Farber, Robert, Fechner, Patricia, Giri, Nagdeep, Nokoff, Natalie, Roberts, Eiry, Sarafoglou, Kyriakie, Sturgeon, Julia, Vogiatzi, Maria, Newfield, Ron
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Pediatric Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9625506/ http://dx.doi.org/10.1210/jendso/bvac150.1281

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