PSAT161 Effect of Hyperlipidemia and Statin Use on the Risk of Dementia and Functional Dependence in the Vietnamese Immigrants

The role of cholesterol in the etiology of dementia is still controversial. Some studies aiming to explore the association between lipids and/or lipid-lowering treatment and dementia indicated a harmful effect of dyslipidemia and a beneficial effect of statin therapy on the risk for dementia. Still, it is not well studied in the Vietnamese population. We sought to evaluate the impact of hyperlipidemia and statin use on the risk of dementia and functional frailty in Vietnamese immigrants.We identified 38(female(F) 26, male(M) 12) community-dwelling Vietnamese patients aged ≥ 55 seen at the cognitive assessment clinic in a community health center 1/2021-8/2021 through chart review. This cohort's mean age(±SD) was 72.3(±9.35). Because lipid panel results were unavailable, 1 patient (F 1) was excluded. We assigned the patients with normal cognitive tests results or a diagnosis of mild cognitive impairment to the control group and those diagnosed with dementia to the study group. To assess function, we obtained ADLs (activities of daily living) and IADLs (instrumental activities of daily living). This study defined hyperlipidemia (HLD) as LDL >100 and functional dependence as dependence in ADLs and/or IADLs.Among 37 patients (F25, M12), 21 patients were diagnosed with dementia (F15, M 6), and 16 patients (F10, M6) were assigned to the control group. In the study group, 19 patients (F13, M 6) were diagnosed with HLD, and 13 patients (F 8, M 5) were taking statins. Fifteen patients (F 10, M 5) were diagnosed with HLD, and 14 patients (F9, M5) were taking statins in the control group. Thirty-three patients (F 23, M 10) were functional dependent. Among them, 31 patients (F 21, M 10) were diagnosed with HLD, and 24 patients (F 15, M 9) were taking statins. Four patients (F 2, M2) were functionally independent, and 3 patients (F 2, M1) were diagnosed with HLD, and all of them were taking statins.The persons with HLD had an about 12% reduction in risk of dementia (RR 0.8382, P=0.6855), but they were about 37% likely to develop functional dependence (RR 1.3676, P=0.4470). Statin users had a nearly 40% reduction in risk of dementia (RR 0.6019, P=0.0462) but the risk for developing functional dependence was not significantly different from non-users (RR 0.9877, P=0.9211). These findings suggested statin treatment has a beneficial effect on decreasing the risk for dementia in patients with HLD, and HLD has a harmful impact on developing functional frailty. This study showed a risk reduction of dementia in patients with HLD, which was different from other study results. More studies with a larger number of patients in this cohort are needed to investigate this further. Presentation: Saturday, June 11, 2022 1:00 p.m. - 3:00 p.m.